Rabbit anti-Human ABCC10 Polyclonal Antibody | anti-ABCC10 antibody

ABCC10, ID (ABCC10, MRP7, SIMRP7, Multidrug resistance-associated protein 7, ATP-binding cassette sub-family C member 10) (MaxLight 750)

Cat. Num. AAA6270417

• Gene Names: ABCC10; MRP7; SIMRP7; EST182763
• Reactivity: Human
• Applications: Flow Cytometry, Functional Assay, Immunohistochemistry, Western Blot
• Purity: Purified by Protein A Affinity Chromatography.
• Synonyms: ABCC10; Polyclonal Antibody; ID (ABCC10; MRP7; SIMRP7; Multidrug resistance-associated protein 7; ATP-binding cassette sub-family C member 10) (MaxLight 750); ATP-binding cassette sub-family C member 10; anti-ABCC10 antibody

• Host: Rabbit
• Reactivity: Human
• Clonality: Polyclonal
• Isotype: IgG
• Purity/Purification: Purified by Protein A Affinity Chromatography.
• Form/Format: Supplied as a liquid in PBS, pH 7.2. No preservative added. Labeled with MaxLight750.

• Applicable Applications for anti-ABCC10 antibody: Flow Cytometry (FC/FACS), FLISA, Immunohistochemistry (IHC), Western Blot (WB)
• Application Notes: FC/FACS: 1:10-50; FLISA: 1:1,000; IHC: 1:50-100; WB: 1:100-500; Applications are based on unconjugated antibody.
• Immunogen: ABCC10 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 774-801 amino acids from the Central region of human ABCC10.
• Conjugate: MaxLight750
• Note: Preservative Free
• Preparation and Storage: Store product at 4 degree C in the dark. DO NOT FREEZE! Stable at 4 degree C for 12 months after receipt as an undiluted liquid. Dilute required amount only prior to immediate use. Further dilutions can be made in assay buffer. Caution: MaxLight750 conjugates are sensitive to light. For maximum recovery of product, centrifuge the original vial prior to removing the cap.

Related Product Information for anti-ABCC10 antibody

The protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra-and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, and White). This ABC full-transporter is a member of the MRP subfamily which is involved in multi-drug resistance. Multiple transcript variants encoding different isoforms have been found for this gene.

Product Categories/Family for anti-ABCC10 antibody

Antibodies; Multi Drug Resistance (MDR)

References

Kuang, Y.H., et al. Biochem. Pharmacol. 79(2):154-161(2010). Saito, A., et al. J. Hum. Genet. 54(6):317-323(2009). Zhou, Y., et al. Biochem. Pharmacol. 77(6):993-1001(2009). Hopper-Borge, E., et al. Cancer Res. 69(1):178-184(2009). Shen, T., et al. PLoS ONE 4 (10), E7520 (2009).

NCBI and Uniprot Product Information

• NCBI GI #: 25914749
• NCBI GeneID: 89845
• NCBI Accession #: NP_258261.2
• NCBI GenBank Nucleotide #: NM_033450.2
• UniProt Accession #: Q5T3U5; Q8NHX7; Q9H7N2; Q9NXY3; Q9UF48
• Molecular Weight: 158,781 Da
• NCBI Official Full Name: multidrug resistance-associated protein 7 isoform MRP7A
• NCBI Official Synonym Full Names: ATP-binding cassette, sub-family C (CFTR/MRP), member 10
• NCBI Official Symbol: ABCC10
• NCBI Official Synonym Symbols: MRP7; SIMRP7; EST182763
• NCBI Protein Information: multidrug resistance-associated protein 7; ATP-binding cassette sub-family C member 10
• UniProt Protein Name: Multidrug resistance-associated protein 7
• Protein Family: ABC transporter C family
• UniProt Gene Name: ABCC10
• UniProt Synonym Gene Names: MRP7; SIMRP7
• UniProt Entry Name: MRP7_HUMAN

NCBI Description

The protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, and White). This ABC full-transporter is a member of the MRP subfamily which is involved in multi-drug resistance. Multiple transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Nov 2010]

Uniprot Description

ABCC10: ATP-dependent transporter probably involved in cellular detoxification through lipophilic anion extrusion. Belongs to the ABC transporter superfamily. ABCC family. Conjugate transporter (TC 3.A.1.208) subfamily. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Transporter; Membrane protein, integral; Membrane protein, multi-pass; Transporter, ABC family

Chromosomal Location of Human Ortholog: 6p21.1

Cellular Component: lysosomal membrane; integral to membrane; plasma membrane

Molecular Function: ATPase activity, coupled to transmembrane movement of substances; ATP binding

Biological Process: metabolic process; transmembrane transport