Rabbit AAK1 Polyclonal Antibody | anti-AAK1 antibody

AAK1 Antibody

Cat. Num. AAA840310

• Gene Names: ZNF630; dJ54B20.2
• Reactivity: Human, Mouse, Rat
• Applications: Western Blot
• Purity: Affinity purified
• Synonyms: AAK1; Polyclonal Antibody; AAK1 Antibody; AAK-1; AKK 1; AP2 associated kinase 1; Adaptor associated kinase 1; anti-AAK1 antibody

• Host: Rabbit
• Reactivity: Human, Mouse, Rat
• Clonality: Polyclonal
• Isotype: IgG
• Purity/Purification: Affinity purified
• Form/Format: 100 ug (0.5 mg/ml) affinity purified rabbit polyclonal antibody in phosphate-buffered saline (PBS) containing 30% glycerol, 0.5% BSA, and 0.01% thimerosal.; Appearance: Colorless liquid
• Concentration: 0.5 mg/ml (varies by lot)
• Sequence Length: 657

• Applicable Applications for anti-AAK1 antibody: Western Blot (WB)
• Application Notes: Western blotting (0.5-4 ug/ml). However, the optimal concentrations should be determined individually. The antibody recognizes ~95 kDa AAK1 in samples from human, mouse and rat origins. Reactivity to other species has not been tested.
• Immunogen: Synthetic peptide surrounding amino acid 850 of human AAK1
• Handling: The antibody solution should be gently mixed before use.
• Preparation and Storage: At -20 degree C; Shelf Life: 12 months

Testing Data

Related Product Information for anti-AAK1 antibody

Background: AAK1 is a serine/threonine kinase that is thomught to coordinate the recruitment of AP-2 to receptors containing tyrosine-based internalization motifs by phosphorylating the u2 subunit. There is strong evidence that this protein is the endogenous mu 2 kinase and plays a regulatory role in clathrin-mediated endocytosis, including the regulation of fatty acid synthesis and cholesterol synthesis.

NCBI and Uniprot Product Information

• NCBI GI #: 170016085
• NCBI GeneID: 57232
• NCBI Accession #: NP_001032824.2
• NCBI GenBank Nucleotide #: NM_001037735.3
• UniProt Accession #: Q2M218; Q5H8Z5; F8WAG4
• Molecular Weight: 74,515 Da
• NCBI Official Full Name: zinc finger protein 630 isoform 1
• NCBI Official Synonym Full Names: zinc finger protein 630
• NCBI Official Symbol: ZNF630
• NCBI Official Synonym Symbols: dJ54B20.2
• NCBI Protein Information: zinc finger protein 630
• UniProt Protein Name: Zinc finger protein 630
• Protein Family: AP2-associated protein kinase
• UniProt Gene Name: ZNF630
• UniProt Entry Name: ZN630_HUMAN

NCBI Description

This gene encodes a protein containing an N-terminal Kruppel-associated box-containing (KRAB) domain and 13 Kruppel-type C2H2 zinc finger domains. This gene resides on an area of chromosome X that has been implicated in nonsyndromic X-linked mental retardation. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2013]

Uniprot Description

ZNF630: May be involved in transcriptional regulation. Belongs to the krueppel C2H2-type zinc-finger protein family.

Protein type: C2H2-type zinc finger protein

Chromosomal Location of Human Ortholog: Xp11.3-p11.1

Cellular Component: nucleus

Molecular Function: DNA binding; metal ion binding; transcription factor activity

Biological Process: transcription, DNA-dependent; regulation of transcription, DNA-dependent