Rabbit anti-Human 5-HT-2A Polyclonal Antibody | anti-5-HT-2A antibody

5-HT-2A Antibody

Cat. Num. AAA9418967

• Gene Names: HTR2A; HTR2; 5-HT2A
• Reactivity: Human
• Applications: Western Blot
• Synonyms: 5-HT-2A; Polyclonal Antibody; 5-HT-2A Antibody; HTR2A; 5-HT2A; 5-HT2a receptor; 5HT2A Receptor; 5-HT-2; 5-HT2A/2C; 5-HT2A/2C receptor; 5-HT2 receptor; HTR2; Serotonin 5-HT-2A receptor; Serotonin receptor 2A; Serotonin 2a receptor; anti-5-HT-2A antibody

• Host: Rabbit
• Reactivity: Human
• Clonality: Polyclonal
• Specificity: 5-HT-2A Antibody detects endogenous levels of total 5-HT-2A
• Form/Format: Rabbit IgG in phosphate buffered saline, pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
• Concentration: 1.0mg/mL (varies by lot)
• Sequence Length: 471

• Applicable Applications for anti-5-HT-2A antibody: Western Blot (WB)
• Application Notes: Western Blot: 1:1000-3000
• Immunogen: A synthesized peptide derived from human 5-HT-2A
• Immunogen Type: Peptide
• Preparation and Storage: Store at -20 degree C

Western Blot (WB)

(Western blot analysis 5-HT-2A using COLO205 whole cell lysates)

Product Categories/Family for anti-5-HT-2A antibody

Total protein Ab

NCBI and Uniprot Product Information

• NCBI GI #: 10835175
• NCBI GeneID: 3356
• NCBI Accession #: NP_000612.1
• NCBI GenBank Nucleotide #: NM_000621.4
• UniProt Accession #: P28223; Q5T8C0; B2RAC5; B4DZ79; F5GWE8
• Molecular Weight: 43,940 Da
• NCBI Official Full Name: 5-hydroxytryptamine receptor 2A isoform 1
• NCBI Official Synonym Full Names: 5-hydroxytryptamine receptor 2A
• NCBI Official Symbol: HTR2A
• NCBI Official Synonym Symbols: HTR2; 5-HT2A
• NCBI Protein Information: 5-hydroxytryptamine receptor 2A
• UniProt Protein Name: 5-hydroxytryptamine receptor 2A
• UniProt Gene Name: HTR2A
• UniProt Synonym Gene Names: HTR2; 5-HT-2; 5-HT-2A
• UniProt Entry Name: 5HT2A_HUMAN

NCBI Description

This gene encodes one of the receptors for serotonin, a neurotransmitter with many roles. Mutations in this gene are associated with susceptibility to schizophrenia and obsessive-compulsive disorder, and are also associated with response to the antidepressant citalopram in patients with major depressive disorder (MDD). MDD patients who also have a mutation in intron 2 of this gene show a significantly reduced response to citalopram as this antidepressant downregulates expression of this gene. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2009]

Uniprot Description

5-HT(2A): This is one of the several different receptors for 5- hydroxytryptamine (serotonin), a biogenic hormone that functions as a neurotransmitter, a hormone, and a mitogen. This receptor mediates its action by association with G proteins that activate a phosphatidylinositol-calcium second messenger system. This receptor is involved in tracheal smooth muscle contraction, bronchoconstriction, and control of aldosterone production. Belongs to the G-protein coupled receptor 1 family.

Protein type: GPCR, family 1; Membrane protein, integral; Membrane protein, multi-pass; Receptor, GPCR

Chromosomal Location of Human Ortholog: 13q14-q21

Cellular Component: dendrite; plasma membrane

Molecular Function: drug binding; neurotransmitter receptor activity; serotonin binding; serotonin receptor activity

Biological Process: cellular calcium ion homeostasis; G-protein signaling, adenylate cyclase inhibiting pathway; G-protein signaling, coupled to IP3 second messenger (phospholipase C activating); phosphoinositide 3-kinase cascade; phospholipase C activation; positive regulation of phosphatidylinositol biosynthetic process; release of sequestered calcium ion into cytosol; response to drug; serotonin receptor signaling pathway; synaptic transmission

Disease: Alcohol Dependence; Anorexia Nervosa, Susceptibility To, 1; Major Depressive Disorder; Obsessive-compulsive Disorder; Schizophrenia