DNA-directed RNA polymerase III subunit RPC6 (Polr3f) Recombinant Protein | Polr3f recombinant protein

Recombinant Mouse DNA-directed RNA polymerase III subunit RPC6 (Polr3f)

Cat. Num. AAA1380349

• Gene Names: Polr3f; RPC6; RPC39; 2810411G20Rik; 3010019O03Rik; 3110032A07Rik
• Purity: Greater or equal to 85% purity as determined by SDS-PAGE.
• Synonyms: DNA-directed RNA polymerase III subunit RPC6 (Polr3f); Recombinant Mouse DNA-directed RNA polymerase III subunit RPC6 (Polr3f); Polr3f recombinant protein

• Host: E Coli or Yeast or Baculovirus or Mammalian Cell
• Purity/Purification: Greater or equal to 85% purity as determined by SDS-PAGE.
• Form/Format: Lyophilized or liquid (Format to be determined during the manufacturing process)
• Sequence Positions: 2-316, full length protein
• Sequence: AEVKVKVQPPDADPVEIENRIIELCHQFPHGITDQVIQNEMPHIEAQQRAVAINRLLSMGQLDLLRSNTGLLYRIKDSQNAGKMKGSDNQEKLVYQIIEDAGNKGIWSRDIRYKSNLPLTEINKILKNLESKKLIKAVKSVAASKKKVYMLYNLQPDRSVTGGAWYSDQDFESEFVEVLNQQCFKFLQSKAETARESKQNPVIQRNSSFASSHEVWKYICELGISKVELSMEDIETILNTLIYDGKVEMTIIAAKEGTVGSVDGHMKLYRAVNPILPPTGVVRAPCGLCPVFEDCHEGGEISPSNCIYMTEWLEF
• Sequence Length: 315

• Species: Mouse
• Preparation and Storage: Store at -20 degrees C. For long-term storage, store at -20 degrees C or -80 degrees C. Store working aliquots at 4 degrees C for up to one week. Repeated freezing and thawing is not recommended.

Related Product Information for Polr3f recombinant protein

This protein is one of more than a dozen subunits forming eukaryotic RNA polymerase III (RNA Pol III), which transcribes 5S ribosomal RNA and tRNA genes. This protein has been shown to bind both TFIIIB90 and TBP, two subunits of RNA polymerase III transcription initiation factor IIIB (TFIIIB). Unlike most of the other RNA Pol III subunits, the encoded protein is unique to this polymerase.

NCBI and Uniprot Product Information

• NCBI GI #: 27754160
• NCBI GeneID: 70408
• NCBI Accession #: NP_084039.2
• NCBI GenBank Nucleotide #: NM_029763.3
• UniProt Accession #: Q921X6; Q544K6
• Molecular Weight: 35,652 Da
• NCBI Official Full Name: DNA-directed RNA polymerase III subunit RPC6
• NCBI Official Synonym Full Names: polymerase (RNA) III (DNA directed) polypeptide F
• NCBI Official Symbol: Polr3f
• NCBI Official Synonym Symbols: RPC6; RPC39; 2810411G20Rik; 3010019O03Rik; 3110032A07Rik
• NCBI Protein Information: DNA-directed RNA polymerase III subunit RPC6
• UniProt Protein Name: DNA-directed RNA polymerase III subunit RPC6
• UniProt Gene Name: Polr3f
• UniProt Synonym Gene Names: RNA polymerase III subunit C6

Uniprot Description

DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Specific peripheric component of RNA polymerase III which synthesizes small RNAs, such as 5S rRNA and tRNAs. May direct RNA Pol III binding to the TFIIIB-DNA complex. Plays a key role in sensing and limiting infection by intracellular bacteria and DNA viruses. Acts as nuclear and cytosolic DNA sensor involved in innate immune response. Can sense non-self dsDNA that serves as template for transcription into dsRNA. The non-self RNA polymerase III transcripts induce type I interferon and NF- Kappa-B through the RIG-I pathway (). Preferentially binds double-stranded DNA (dsDNA) ().