Mouse polymerase (RNA) III (DNA directed) polypeptide B ELISA Kit | POLR3B elisa kit

Mouse DNA-directed RNA polymerase III subunit RPC2, POLR3B ELISA Kit

Cat. Num. AAA9335390

• Gene Names: Polr3b; RPC2; C85372; 2700078H01Rik; A330032P03Rik
• Reactivity: Mouse
• Synonyms: polymerase (RNA) III (DNA directed) polypeptide B; Mouse DNA-directed RNA polymerase III subunit RPC2; POLR3B ELISA Kit; Mouse DNA-directed RNA polymerase III subunit RPC2 (POLR3B) ELISA kit; C128; DKFZp686B10117; FLJ10388; RPC2; DNA-directed RNA polymerase III 127.6 kDa; DNA-directed RNA polymerase III B; DNA-directed RNA polymerase III subunit B; RNA polymerase III subunit C2; POLR3B elisa kit

• Reactivity: Mouse

• Preparation and Storage: Store all reagents at 2-8 degree C

NCBI and Uniprot Product Information

• NCBI GI #: 46195739
• NCBI GeneID: 70428
• NCBI Accession #: NP_081699.1
• NCBI GenBank Nucleotide #: NM_027423.1
• UniProt Accession #: P59470; Q6NVF3
• Molecular Weight: 127,715 Da
• NCBI Official Full Name: DNA-directed RNA polymerase III subunit RPC2
• NCBI Official Synonym Full Names: polymerase (RNA) III (DNA directed) polypeptide B
• NCBI Official Symbol: Polr3b
• NCBI Official Synonym Symbols: RPC2; C85372; 2700078H01Rik; A330032P03Rik
• NCBI Protein Information: DNA-directed RNA polymerase III subunit RPC2; C128; RNA polymerase III subunit C2; DNA-directed RNA polymerase III B; RNA polymerase III subunit RPC2 homolog; DNA-directed RNA polymerase III subunit B; DNA-directed RNA polymerase III 127.6 kDa polypeptide
• UniProt Protein Name: DNA-directed RNA polymerase III subunit RPC2
• UniProt Gene Name: Polr3b
• UniProt Synonym Gene Names: RNA polymerase III subunit C2
• UniProt Entry Name: RPC2_MOUSE

Uniprot Description

POLR3B: DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Second largest core component of RNA polymerase III which synthesizes small RNAs, such as 5S rRNA and tRNAs. Proposed to contribute to the polymerase catalytic activity and forms the polymerase active center together with the largest subunit. Pol III is composed of mobile elements and RPC2 is part of the core element with the central large cleft and probably a clamp element that moves to open and close the cleft. Plays a key role in sensing and limiting infection by intracellular bacteria and DNA viruses. Acts as nuclear and cytosolic DNA sensor involved in innate immune response. Can sense non-self dsDNA that serves as template for transcription into dsRNA. The non-self RNA polymerase III transcripts, such as Epstein-Barr virus-encoded RNAs (EBERs) induce type I interferon and NF- Kappa-B through the RIG-I pathway. Defects in POLR3B are the cause of leukodystrophy, hypomyelinating, type 8, with or without oligodontia and/or hypogonadotropic hypogonadism (HLD8). An autosomal recessive neurodegenerative disorder characterized by early childhood onset of cerebellar ataxia and mild intellectual disabilities associated with diffuse hypomyelination apparent on brain MRI. Variable features include oligodontia and/or hypogonadotropic hypogonadism. Belongs to the RNA polymerase beta chain family.

Protein type: Transferase; Nucleotide Metabolism - purine; EC 2.7.7.6; Transcription initiation complex; Nucleotide Metabolism - pyrimidine

Cellular Component: DNA-directed RNA polymerase III complex; nucleus

Molecular Function: transferase activity; DNA binding; DNA-directed RNA polymerase activity; ribonucleoside binding; metal ion binding; nucleotidyltransferase activity

Biological Process: transcription, DNA-dependent; immune system process; positive regulation of innate immune response; positive regulation of interferon-beta production; innate immune response; defense response to virus