DNA-directed RNA polymerase II subunit GRINL1A (Polr2m) Recombinant Protein | Polr2m recombinant protein

Recombinant Rat DNA-directed RNA polymerase II subunit GRINL1A (Polr2m)

Cat. Num. AAA1410938

• Gene Names: Polr2m; Glurr; Grinl1a
• Purity: Greater or equal to 85% purity as determined by SDS-PAGE.
• Synonyms: DNA-directed RNA polymerase II subunit GRINL1A (Polr2m); Recombinant Rat DNA-directed RNA polymerase II subunit GRINL1A (Polr2m); Polr2m recombinant protein

• Host: E Coli or Yeast or Baculovirus or Mammalian Cell
• Purity/Purification: Greater or equal to 85% purity as determined by SDS-PAGE.
• Form/Format: Lyophilized or liquid (Format to be determined during the manufacturing process)
• Sequence Positions: 1-364, full length protein
• Sequence: MCSLPRGFEPPAPEDLGRQSSAELRERLRRQERLLRNEKFICKLPDKGKKISDTIAKLKAAISEREEVRGRTELFHPVSVDCKLRHKATTRVDTDIDKAQNSDLMLDTSSLVPECSSVDIESSKTTSETQGPTHLTHKGNEETLATGCTVNTCPSARITTQDPSSEVNEHLPQHSSQVEEISSSVDSLFITKLQKITIADQTEPSEENTSTENFPGLQSETPKKPHYMKVLEMRAKNPVPPPHKFKTNVLPTQQSDSSSHCHKGQSPASSEEHRRRARQHLDDVTAARLLPLHHLPAQLLSIEESLALQKEQKQNYEEMQAKLAAQKLAERLNIKMQSFNPEGESSGRYREVRDEDDAQSSDEC
• Sequence Length: 364

• Species: Rat
• Preparation and Storage: Store at -20 degrees C. For long-term storage, store at -20 degrees C or -80 degrees C. Store working aliquots at 4 degrees C for up to one week. Repeated freezing and thawing is not recommended.

Related Product Information for Polr2m recombinant protein

This gene (GRINL1A) is part of a complex transcript unit that includes the gene for GRINL1A combined protein (Gcom1). Transcription of this gene occurs at a downstream promoter, with at least three different alternatively spliced variants, grouped together as Gdown for GRINL1A downstream transcripts. The Gcom1 gene uses an upstream promoter for transcription and also has multiple alternatively spliced variants.

NCBI and Uniprot Product Information

• NCBI GI #: 34447223
• NCBI GeneID: 192147
• NCBI Accession #: NP_899652.1
• NCBI GenBank Nucleotide #: NM_183402.1
• UniProt Accession #: Q91XQ4
• Molecular Weight: 40,874 Da
• NCBI Official Full Name: DNA-directed RNA polymerase II subunit GRINL1A
• NCBI Official Synonym Full Names: RNA polymerase II subunit M
• NCBI Official Symbol: Polr2m
• NCBI Official Synonym Symbols: Glurr; Grinl1a
• NCBI Protein Information: DNA-directed RNA polymerase II subunit GRINL1A
• UniProt Protein Name: DNA-directed RNA polymerase II subunit GRINL1A
• Protein Family: DNA-directed RNA polymerase
• UniProt Gene Name: Polr2m
• UniProt Synonym Gene Names: Grinl1a

NCBI Description

putative glutamate receptor that may have a role in susceptibility to autism [RGD, Feb 2006]

Uniprot Description

Appears to be stable component of the Pol II(G) complex form of RNA polymerase II. Pol II synthesizes mRNA precursors and many functional non-coding RNAs and is the central component of the basal RNA polymerase II transcription machinery. May play a role in Mediator-dependent regulation of transcription activation. In vitro, acts as negative regulator of transcriptional activation; this repression is relieved by the Mediator complex, which restores Pol II(G) activator-dependent transcription to a level equivalent to that of Pol II ().