Rat polymerase (RNA) I polypeptide A, 194kDa ELISA Kit | POLR1A elisa kit
Rat DNA-directed RNA polymerase I subunit RPA1, POLR1A ELISA Kit
NCBI and Uniprot Product Information
NCBI Description
subunit of RNA polymerase I [RGD, Feb 2006]
Uniprot Description
POLR1A: DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Largest and catalytic core component of RNA polymerase I which synthesizes ribosomal RNA precursors. Forms the polymerase active center together with the second largest subunit. A single stranded DNA template strand of the promoter is positioned within the central active site cleft of Pol I. A bridging helix emanates from RPA1 and crosses the cleft near the catalytic site and is thought to promote translocation of Pol I by acting as a ratchet that moves the RNA-DNA hybrid through the active site by switching from straight to bent conformations at each step of nucleotide addition. Belongs to the RNA polymerase beta' chain family.
Protein type: Nucleotide Metabolism - purine; Transcription initiation complex; EC 2.7.7.6; Nucleolus; Transferase; Nucleotide Metabolism - pyrimidine
Cellular Component: cytoplasm; nucleolus; nucleus; DNA-directed RNA polymerase I complex
Molecular Function: DNA binding; zinc ion binding; DNA-directed RNA polymerase activity
Biological Process: transcription, DNA-dependent; transcription from RNA polymerase I promoter; rRNA transcription
Research Articles on POLR1A
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Product Notes
The Rat POLR1A polr1a (Catalog #AAA9316328) is an ELISA Kit and is intended for research purposes only. The product is available for immediate purchase. The AAA9316328 ELISA Kit recognizes Rat POLR1A. It is sometimes possible for the material contained within the vial of "polymerase (RNA) I polypeptide A, 194kDa, ELISA Kit" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
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