WDR51B Blocking Peptide | POC1B blocking peptide

WDR51B Blocking Peptide (C-term)

• Gene Names: POC1B; PIX1; CORD20; TUWD12; WDR51B
• Synonyms: WDR51B; WDR51B Blocking Peptide (C-term); POC1 centriolar protein homolog B; Pix1; Proteome of centriole protein 1B; WD repeat-containing protein 51B; POC1B; POC1B blocking peptide

• Specificity: The synthetic peptide sequence is selected from aa 406-417 of HUMAN POC1B
• Form/Format: Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.
• Sequence Length: 478

• Cellular Location: Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriole Cytoplasm, cytoskeleton, cilium basal body. Cytoplasm, cytoskeleton, spindle pole. Note: Component of both mother and daughter centrioles Localizes to the basal body and centriole adjacent to the connecting cilium of photoreceptors and in synapses of the outer plexiform layer.
• Tissue Location: Expressed in the retina.
• Preparation and Storage: Maintain refrigerated at 2-8 degree C for up to 6 months. For long term storage store at -20 degree C.

Related Product Information for POC1B blocking peptide

Plays an important role in centriole assembly and/or stability and ciliogenesis (PubMed:20008567). Involved in early steps of centriole duplication, as well as in the later steps of centriole length control (PubMed:19109428). Acts in concert with POC1A to ensure centriole integrity and proper mitotic spindle formation. Required for primary cilia formation, ciliary length and also cell proliferation (PubMed:23015594). Required for retinal integrity (PubMed:25044745).

NCBI and Uniprot Product Information

• NCBI GI #: 74762610
• NCBI GeneID: 282809
• UniProt Accession #: Q8TC44; G3V1X0
• Molecular Weight: 49,104 Da
• NCBI Official Full Name: POC1 centriolar protein homolog B
• NCBI Official Synonym Full Names: POC1 centriolar protein B
• NCBI Official Symbol: POC1B
• NCBI Official Synonym Symbols: PIX1; CORD20; TUWD12; WDR51B
• NCBI Protein Information: POC1 centriolar protein homolog B
• UniProt Protein Name: POC1 centriolar protein homolog B
• Protein Family: POC1 centriolar protein
• UniProt Gene Name: POC1B
• UniProt Synonym Gene Names: WDR51B
• UniProt Entry Name: POC1B_HUMAN

NCBI Description

POC1 proteins contain an N-terminal WD40 domain and a C-terminal coiled coil domain and are part of centrosomes. They play an important role in basal body and cilia formation. This gene encodes one of the two POC1 proteins found in humans. Mutation in this gene result in autosomal-recessive cone-rod dystrophy. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Oct 2014]

Uniprot Description

WDR51B: Required for ciliogenesis. Belongs to the WD repeat POC1 family.

Chromosomal Location of Human Ortholog: 12q21.33

Cellular Component: centriole; centrosome; spindle pole

Molecular Function: protein binding

Biological Process: cell proliferation; cilium biogenesis; retinal homeostasis

Disease: Cone-rod Dystrophy 20