Transmembrane prostate androgen-induced protein (Pmepa1) Recombinant Protein | Pmepa1 recombinant protein

Recombinant Mouse Transmembrane prostate androgen-induced protein (Pmepa1), partial

• Gene Names: Pmepa1; Stag1; Erg1.2; N4wbp4; Tmepai; AW455466; 2210418I02Rik
• Purity: Greater or equal to 85% purity as determined by SDS-PAGE.
• Synonyms: Transmembrane prostate androgen-induced protein (Pmepa1); Recombinant Mouse Transmembrane prostate androgen-induced protein (Pmepa1); partial; Pmepa1 recombinant protein

• Host: E Coli or Yeast or Baculovirus or Mammalian Cell
• Purity/Purification: Greater or equal to 85% purity as determined by SDS-PAGE.
• Form/Format: Lyophilized or liquid (Format to be determined during the manufacturing process)
• Sequence Length: 260

• Species: Mouse
• Preparation and Storage: Store at -20 degrees C. For long-term storage, store at -20 degrees C or -80 degrees C. Store working aliquots at 4 degrees C for up to one week. Repeated freezing and thawing is not recommended.

NCBI and Uniprot Product Information

• NCBI GI #: 20140783
• NCBI GeneID: 65112
• UniProt Accession #: Q9D7R2; Q9EQH9
• Molecular Weight: 28,716 Da
• NCBI Official Full Name: Protein TMEPAI
• NCBI Official Synonym Full Names: prostate transmembrane protein, androgen induced 1
• NCBI Official Symbol: Pmepa1
• NCBI Official Synonym Symbols: Stag1; Erg1.2; N4wbp4; Tmepai; AW455466; 2210418I02Rik
• NCBI Protein Information: protein TMEPAI
• UniProt Protein Name: Protein TMEPAI
• Protein Family: Protein
• UniProt Gene Name: Pmepa1
• UniProt Synonym Gene Names: N4wbp4; Tmepai

Uniprot Description

Functions as a negative regulator of TGF-beta signaling and thereby probably plays a role in cell proliferation, differentiation, apoptosis, motility, extracellular matrix production and immunosuppression. In the canonical TGF-beta pathway, ZFYVE9/SARA recruits the intracellular signal transducer and transcriptional modulators SMAD2 and SMAD3 to the TGF-beta receptor. Phosphorylated by the receptor, SMAD2 and SMAD3 then form a heteromeric complex with SMAD4 that translocates to the nucleus to regulate transcription. Through interaction with SMAD2 and SMAD3, LDLRAD4 may compete with ZFYVE9 and SMAD4 and prevent propagation of the intracellular signal (PubMed:20129061). Also involved in down-regulation of the androgen receptor (AR), enhancing ubiquitination and proteasome-mediated degradation of AR, probably by recruiting NEDD4.