Plexin-A2 (PLXNA2) Recombinant Protein | PLXNA2 recombinant protein

Recombinant Human Plexin-A2 (PLXNA2) , partial

• Gene Names: PLXNA2; OCT; PLXN2
• Purity: Greater or equal to 85% purity as determined by SDS-PAGE.
• Synonyms: Plexin-A2 (PLXNA2); Recombinant Human Plexin-A2 (PLXNA2); partial; PLXNA2 recombinant protein

• Host: E Coli or Yeast or Baculovirus or Mammalian Cell
• Purity/Purification: Greater or equal to 85% purity as determined by SDS-PAGE.
• Form/Format: Lyophilized or liquid (Format to be determined during the manufacturing process)
• Sequence Length: 552

• Species: Human
• Preparation and Storage: Store at -20 degrees C. For long-term storage, store at -20 degrees C or -80 degrees C. Store working aliquots at 4 degrees C for up to one week. Repeated freezing and thawing is not recommended.

Related Product Information for PLXNA2 recombinant protein

This gene encodes a member of the plexin-A family of semaphorin co-receptors. Semaphorins are a large family of secreted or membrane-bound proteins that mediate repulsive effects on axon pathfinding during nervous system development. A subset of semaphorins are recognized by plexin-A
neuropilin transmembrane receptor complexes, triggering a cellular signal transduction cascade that leads to axon repulsion. This plexin-A family member is thought to transduce signals from semaphorin-3A and -3C.

NCBI and Uniprot Product Information

• NCBI GI #: 113722116
• NCBI GeneID: 5362
• NCBI Accession #: NP_079455.3
• NCBI GenBank Nucleotide #: NM_025179.3
• UniProt Accession #: O75051; Q6UX61; Q96GN9; Q9BRL1; Q9UIW1; A2RTX9; B2RMX7
• Molecular Weight: 61,649 Da
• NCBI Official Full Name: plexin-A2
• NCBI Official Synonym Full Names: plexin A2
• NCBI Official Symbol: PLXNA2
• NCBI Official Synonym Symbols: OCT; PLXN2
• NCBI Protein Information: plexin-A2
• UniProt Protein Name: Plexin-A2
• Protein Family: Plexin
• UniProt Gene Name: PLXNA2
• UniProt Synonym Gene Names: KIAA0463; OCT; PLXN2

NCBI Description

This gene encodes a member of the plexin-A family of semaphorin co-receptors. Semaphorins are a large family of secreted or membrane-bound proteins that mediate repulsive effects on axon pathfinding during nervous system development. A subset of semaphorins are recognized by plexin-A/neuropilin transmembrane receptor complexes, triggering a cellular signal transduction cascade that leads to axon repulsion. This plexin-A family member is thought to transduce signals from semaphorin-3A and -3C. [provided by RefSeq, Jul 2008]

Uniprot Description

Coreceptor for SEMA3A and SEMA6A. Necessary for signaling by SEMA6A and class 3 semaphorins and subsequent remodeling of the cytoskeleton. Plays a role in axon guidance, invasive growth and cell migration. Class 3 semaphorins bind to a complex composed of a neuropilin and a plexin. The plexin modulates the affinity of the complex for specific semaphorins, and its cytoplasmic domain is required for the activation of down-stream signaling events in the cytoplasm ().