MyoGEF Blocking Peptide | PLEKHG6 blocking peptide
MyoGEF Antibody (N-term) Blocking Peptide
Gene Names
PLEKHG6; MyoGEF
Synonyms
MyoGEF; MyoGEF Antibody (N-term) Blocking Peptide; Pleckstrin homology domain-containing family G member 6; PH domain-containing family G member 6; Myosin-interacting guanine nucleotide exchange factor; PLEKHG6; PLEKHG6 blocking peptide
Specificity
The synthetic peptide sequence used to generate the antibody was selected from the N-term region of human MyoGEF. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.
Form/Format
Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.
Sequence Length
790
Cellular Location
Cytoplasm. Cytoplasm, cytoskeleton, spindle. Cytoplasm, cytoskeleton, spindle pole. Cleavage furrow Note: During mitosis, localizes to the spindle pole, central spindle and cleavage furrow. In epithelial cells, recruited to the apical membrane by EZR
Tissue Location
Highest expression in the placenta. Low levels in small intestine, lung, liver, kidney, thymus and heart
Preparation and Storage
Maintain refrigerated at 2-8 degree C for up to 6 months. For long term storage store at -20 degree C.
Related Product Information for PLEKHG6 blocking peptide
Guanine nucleotide exchange factor activating the small GTPase RHOA, which, in turn, induces myosin filament formation. Also activates RHOG. Does not activate RAC1, or to a much lower extent than RHOA and RHOG. Part of a functional unit, involving PLEKHG6, MYH10 and RHOA, at the cleavage furrow to advance furrow ingression during cytokinesis. In epithelial cells, required for the formation of microvilli and membrane ruffles on the apical pole. Along with EZR, required for normal macropinocytosis.
NCBI and Uniprot Product Information
NCBI GI #
NCBI GeneID
Molecular Weight
35,568 Da
NCBI Official Full Name
Pleckstrin homology domain-containing family G member 6
NCBI Official Synonym Full Names
pleckstrin homology and RhoGEF domain containing G6
NCBI Official Symbol
PLEKHG6
NCBI Official Synonym Symbols
MyoGEF
NCBI Protein Information
pleckstrin homology domain-containing family G member 6
UniProt Protein Name
Pleckstrin homology domain-containing family G member 6
Protein Family
UniProt Gene Name
PLEKHG6
UniProt Synonym Gene Names
PH domain-containing family G member 6; MyoGEF
UniProt Entry Name
PKHG6_HUMAN
Uniprot Description
PLEKHG6: Guanine nucleotide exchange factor activating the small GTPase RHOA, which, in turn, induces myosin filament formation. Also activates RHOG. Does not activate RAC1, or to a much lower extent than RHOA and RHOG. Part of a functional unit, involving PLEKHG6, MYH10 and RHOA, at the cleavage furrow to advance furrow ingression during cytokinesis. In epithelial cells, required for the formation of microvilli and membrane ruffles on the apical pole. Along with EZR, required for normal macropinocytosis. 3 isoforms of the human protein are produced by alternative splicing.
Protein type: GEFs; GEFs, Rac/Rho
Chromosomal Location of Human Ortholog: 12p13.31
Molecular Function: protein binding
Research Articles on PLEKHG6
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Product Notes
The PLEKHG6 plekhg6 (Catalog #AAA9226430) is a Blocking Peptide and is intended for research purposes only. The product is available for immediate purchase. It is sometimes possible for the material contained within the vial of "MyoGEF, Blocking Peptide" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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