Western Blot (WB)
(Western blot detection of Ezrin in MCF7, 3T3, A549 and Rat Brain lysates using Ezrin mouse mAb (dilution 1:1000).Predicted band size:69kDa.Observed band size:81kDa.)
Mouse Ezrin Monoclonal Antibody | anti-EZR-N antibody
Anti-Ezrin Mouse mAb
Western Blot (WB)
(Western blot detection of Ezrin in MCF7, 3T3, A549 and Rat Brain lysates using Ezrin mouse mAb (dilution 1:1000).Predicted band size:69kDa.Observed band size:81kDa.)
Western Blot (WB)
(Western blot detection of Ezrin in MCF7, 3T3, A549 and Rat Brain lysates using Ezrin mouse mAb (dilution 1:1000).Predicted band size:69kDa.Observed band size:81kDa.)
UniPort Summary Function: Probably involved in connections of major cytoskeletal structures to the plasma membrane. In epithelial cells, required for the formation of microvilli and membrane ruffles on the apical pole. Along with PLEKHG6, required for normal macropinocytosis.
NCBI and Uniprot Product Information
NCBI Description
The cytoplasmic peripheral membrane protein encoded by this gene functions as a protein-tyrosine kinase substrate in microvilli. As a member of the ERM protein family, this protein serves as an intermediate between the plasma membrane and the actin cytoskeleton. This protein plays a key role in cell surface structure adhesion, migration and organization, and it has been implicated in various human cancers. A pseudogene located on chromosome 3 has been identified for this gene. Alternatively spliced variants have also been described for this gene. [provided by RefSeq, Jul 2008]
Uniprot Description
Ezrin: a member of the ERM family which includes radixin and moesin. ERM proteins appear to function as cross-linkers between plasma membranes and actin-based cytoskeletons. Plays a key role in cell surface structure adhesion, migration, and organization.
Protein type: Cytoskeletal; Motility/polarity/chemotaxis
Chromosomal Location of Human Ortholog: 6q25.3
Cellular Component: actin cytoskeleton; actin filament; apical part of cell; apical plasma membrane; basolateral plasma membrane; brush border; cell projection; cell-cell adherens junction; cortical cytoskeleton; cytoplasm; cytosol; endosome; extracellular space; extrinsic to membrane; filopodium; focal adhesion; immunological synapse; membrane; microvillus; nucleolus; perinuclear region of cytoplasm; plasma membrane; ruffle; vesicle
Molecular Function: actin binding; actin filament binding; ATPase binding; cell adhesion molecule binding; microtubule binding; protein binding; protein domain specific binding
Biological Process: actin cytoskeleton reorganization; actin filament bundle formation; astral microtubule organization and biogenesis; axon guidance; cortical microtubule organization and biogenesis; establishment of centrosome localization; establishment of epithelial cell polarity; filopodium formation; gland morphogenesis; leukocyte adhesion; membrane to membrane docking; microvillus biogenesis; negative regulation of T cell receptor signaling pathway; negative regulation of transcription from RNA polymerase II promoter; phosphoinositide-mediated signaling; positive regulation of protein secretion; regulation of actin cytoskeleton organization and biogenesis; regulation of cell shape; regulation of cell size
Research Articles on EZR-N
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Product Notes
The EZR-N ezr (Catalog #AAA475574) is an Antibody produced from Mouse and is intended for research purposes only. The product is available for immediate purchase. The Anti-Ezrin Mouse mAb reacts with Human, Mouse, Rat and may cross-react with other species as described in the data sheet. AAA Biotech's Ezrin can be used in a range of immunoassay formats including, but not limited to, Western Blot (WB). WB: 1:1000. Researchers should empirically determine the suitability of the EZR-N ezr for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "Ezrin, Monoclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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