Plant Integrin Alpha V (ITGAV) ELISA Kit | ITGAV elisa kit

Plant Integrin Alpha V (ITGAV) ELISA Kit

• Gene Names: ITGAV; CD51; MSK8; VNRA; VTNR
• Reactivity: Plant
• Synonyms: Integrin Alpha V (ITGAV); Plant Integrin Alpha V (ITGAV) ELISA Kit; ITGAV elisa kit

• Reactivity: Plant
• Sequence Length: 62

• Preparation and Storage: Store all reagents at 2-8 degree C

NCBI and Uniprot Product Information

• NCBI GI #: 466372
• NCBI GeneID: 3685
• Molecular Weight: 111,132 Da
• NCBI Official Full Name: integrin alpha v, partial
• NCBI Official Synonym Full Names: integrin subunit alpha V
• NCBI Official Symbol: ITGAV
• NCBI Official Synonym Symbols: CD51; MSK8; VNRA; VTNR
• NCBI Protein Information: integrin alpha-V
• UniProt Protein Name: Integrin alpha-V
• Protein Family: Integrin
• UniProt Gene Name: ITGAV
• UniProt Synonym Gene Names: MSK8; VNRA
• UniProt Entry Name: ITAV_HUMAN

NCBI Description

The product of this gene belongs to the integrin alpha chain family. Integrins are heterodimeric integral membrane proteins composed of an alpha subunit and a beta subunit that function in cell surface adhesion and signaling. The encoded preproprotein is proteolytically processed to generate light and heavy chains that comprise the alpha V subunit. This subunit associates with beta 1, beta 3, beta 5, beta 6 and beta 8 subunits. The heterodimer consisting of alpha V and beta 3 subunits is also known as the vitronectin receptor. This integrin may regulate angiogenesis and cancer progression. Alternative splicing results in multiple transcript variants. Note that the integrin alpha 5 and integrin alpha V subunits are encoded by distinct genes. [provided by RefSeq, Oct 2015]

Uniprot Description

ITGAV: The alpha-V integrins are receptors for vitronectin, cytotactin, fibronectin, fibrinogen, laminin, matrix metalloproteinase-2, osteopontin, osteomodulin, prothrombin, thrombospondin and vWF. They recognize the sequence R-G-D in a wide array of ligands. In case of HIV-1 infection, the interaction with extracellular viral Tat protein seems to enhance angiogenesis in Kaposi's sarcoma lesions. Belongs to the integrin alpha chain family. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Membrane protein, integral; Cell adhesion; Motility/polarity/chemotaxis

Chromosomal Location of Human Ortholog: 2q31-q32

Cellular Component: cell surface; filopodium membrane; focal adhesion; integrin complex; membrane; microvillus membrane; phagocytic vesicle; plasma membrane

Molecular Function: C-X3-C chemokine binding; coreceptor activity; extracellular matrix binding; fibroblast growth factor binding; fibronectin binding; insulin-like growth factor I binding; opsonin binding; protease binding; protein binding; protein kinase C binding; transforming growth factor beta binding; voltage-gated calcium channel activity

Biological Process: angiogenesis; antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent; cell adhesion; cell growth; cell migration; cell-matrix adhesion; cell-substrate adhesion; entry of virus into host cell; extracellular matrix organization and biogenesis; heterotypic cell-cell adhesion; leukocyte migration; negative chemotaxis; negative regulation of lipid transport; negative regulation of lipoprotein metabolic process; negative regulation of low-density lipoprotein receptor biosynthetic process; positive regulation of cell adhesion; positive regulation of cell proliferation; regulation of phagocytosis; vascular endothelial growth factor receptor signaling pathway