Plant Hedgehog Homolog, Indian (IHH) ELISA Kit | IHH elisa kit

Plant Hedgehog Homolog, Indian (IHH) ELISA Kit

• Gene Names: IHH; BDA1; HHG2
• Reactivity: Plant
• Synonyms: Hedgehog Homolog; Indian (IHH); Plant Hedgehog Homolog; Indian (IHH) ELISA Kit; IHH elisa kit

• Reactivity: Plant
• Sequence Length: 293

• Preparation and Storage: Store all reagents at 2-8 degree C

NCBI and Uniprot Product Information

• NCBI GI #: 823671736
• NCBI GeneID: 3549
• Molecular Weight: 45,251 Da
• NCBI Official Full Name: IHH, partial
• NCBI Official Synonym Full Names: indian hedgehog
• NCBI Official Symbol: IHH
• NCBI Official Synonym Symbols: BDA1; HHG2
• NCBI Protein Information: indian hedgehog protein
• UniProt Protein Name: Indian hedgehog protein
• Protein Family: Indian hedgehog protein
• UniProt Gene Name: IHH
• UniProt Synonym Gene Names: IHH
• UniProt Entry Name: IHH_HUMAN

NCBI Description

This gene encodes a member of the hedgehog family of proteins. The encoded preproprotein is proteolytically processed to generate multiple protein products, including an N-terminal fragment that is involved in signaling. Hedgehog family proteins are essential secreted signaling molecules that regulate a variety of developmental processes including growth, patterning and morphogenesis. The protein encoded by this gene specifically plays a role in bone growth and differentiation. Mutations in this gene are the cause of brachydactyly type A1, which is characterized by shortening or malformation of the fingers and toes. Mutations in this gene are also the cause of acrocapitofemoral dysplasia. [provided by RefSeq, Nov 2015]

Uniprot Description

IHH: Intercellular signal essential for a variety of patterning events during development. Binds to the patched (PTC) receptor, which functions in association with smoothened (SMO), to activate the transcription of target genes. Implicated in endochondral ossification: may regulate the balance between growth and ossification of the developing bones. Induces the expression of parathyroid hormone-related protein (PTHRP). Expressed in embryonic lung, and in adult kidney and liver. Belongs to the hedgehog family.

Chromosomal Location of Human Ortholog: 2q33-q35

Cellular Component: plasma membrane

Molecular Function: calcium ion binding; patched binding

Biological Process: heart looping; negative regulation of alpha-beta T cell differentiation; negative regulation of immature T cell proliferation in the thymus; negative regulation of T cell differentiation in the thymus; positive regulation of alpha-beta T cell differentiation; positive regulation of smoothened signaling pathway; positive regulation of T cell differentiation in the thymus; skeletal development; smoothened signaling pathway

Disease: Acrocapitofemoral Dysplasia; Brachydactyly, Type A1