Polycystin-1 (PKD1) Recombinant Protein | PKD1 recombinant protein

Recombinant Human Polycystin-1 (PKD1) , partial

Cat. Num. AAA953883

• Gene Names: PKD1; PBP; PC1; Pc-1; TRPP1
• Purity: Greater or equal to 85% purity as determined by SDS-PAGE.
• Synonyms: Polycystin-1 (PKD1); Recombinant Human Polycystin-1 (PKD1); partial; PKD1 recombinant protein

• Host: E Coli or Yeast or Baculovirus or Mammalian Cell
• Purity/Purification: Greater or equal to 85% purity as determined by SDS-PAGE.
• Form/Format: Lyophilized or liquid (Format to be determined during the manufacturing process)
• Sequence Positions: 25-636aa; partial
• Sequence: GPGRGCGPCEPPCLCGPAPGAACRVNCSGRGLRTLGPALRIPADATALDVSHNLLRALDVGLLANLSALAELDISNNKISTLEEGIFANLFNLSEINLSGNPFECDCGLAWLPRWAEEQQVRVVQPEAATCAGPGSLAGQPLLGIPLLDSGCGEEYVACLPDNSSGTVAAVSFSAAHEGLLQPEACSAFCFSTGQGLAALSEQGWCLCGAAQPSSASFACLSLCSGPPPPPAPTCRGPTLLQHVFPASPGATLVGPHGPLASGQLAAFHIAAPLPVTATRWDFGDGSAEVDAAGPAASHRYVLPGRYHVTAVLALGAGSALLGTDVQVEAAPAALELVCPSSVQSDESLDLSIQNRGGSGLEAAYSIVALGEEPARAVHPLCPSDTEIFPGNGHCYRLVVEKAAWLQAQEQCQAWAGAALAMVDSPAVQRFLVSRVTRSLDVWIGFSTVQGVEVGPAPQGEAFSLESCQNWLPGEPHPATAEHCVRLGPTGWCNTDLCSAPHSYVCELQPGGPVQDAENLLVGAPSGDLQGPLTPLAQQDGLSAPHEPVEVMVFPGLRLSREAFLTTAEFGTQELRRPAQLRLQVYRLLSTAGTPENGSEPESRSPDNRTQL

• Species: Homo sapiens (Human)
• Preparation and Storage: Store at -20 degrees C. For long-term storage, store at -20 degrees C or -80 degrees C. Store working aliquots at 4 degrees C for up to one week. Repeated freezing and thawing is not recommended.

NCBI and Uniprot Product Information

• NCBI GI #: 205360962
• NCBI GeneID: 5310
• NCBI Accession #: NP_000287.3
• NCBI GenBank Nucleotide #: NM_000296.3
• UniProt Accession #: P98161; Q15140; Q15141
• Molecular Weight: 462,401 Da
• NCBI Official Full Name: polycystin-1 isoform 2
• NCBI Official Synonym Full Names: polycystin 1, transient receptor potential channel interacting
• NCBI Official Symbol: PKD1
• NCBI Official Synonym Symbols: PBP; PC1; Pc-1; TRPP1
• NCBI Protein Information: polycystin-1
• UniProt Protein Name: Polycystin-1
• Protein Family: Polycystin
• UniProt Gene Name: PKD1
• UniProt Synonym Gene Names: PC1

NCBI Description

This gene encodes a member of the polycystin protein family. The encoded glycoprotein contains a large N-terminal extracellular region, multiple transmembrane domains and a cytoplasmic C-tail. It is an integral membrane protein that functions as a regulator of calcium permeable cation channels and intracellular calcium homoeostasis. It is also involved in cell-cell/matrix interactions and may modulate G-protein-coupled signal-transduction pathways. It plays a role in renal tubular development, and mutations in this gene cause autosomal dominant polycystic kidney disease type 1 (ADPKD1). ADPKD1 is characterized by the growth of fluid-filled cysts that replace normal renal tissue and result in end-stage renal failure. Splice variants encoding different isoforms have been noted for this gene. Also, six pseudogenes, closely linked in a known duplicated region on chromosome 16p, have been described. [provided by RefSeq, Oct 2008]

Uniprot Description

Involved in renal tubulogenesis (PubMed:12482949). Involved in fluid-flow mechanosensation by the primary cilium in renal epithelium (). Acts as a regulator of cilium length, together with PKD2 (). The dynamic control of cilium length is essential in the regulation of mechanotransductive signaling (). The cilium length response creates a negative feedback loop whereby fluid shear-mediated deflection of the primary cilium, which decreases intracellular cAMP, leads to cilium shortening and thus decreases flow-induced signaling (). May be an ion-channel regulator. Involved in adhesive protein-protein and protein-carbohydrate interactions.