Phosphatidylinositol 5-phosphate 4-kinase type-2 alpha (PIP4K2A) Recombinant Protein | PIP4K2A recombinant protein

Recombinant Human Phosphatidylinositol 5-phosphate 4-kinase type-2 alpha (PIP4K2A)

Cat. Num. AAA964407

• Gene Names: PIP4K2A; PIPK; PI5P4KA; PIP5K2A; PIP5KIIA; PIP5KII-alpha
• Purity: Greater or equal to 85% purity as determined by SDS-PAGE.
• Synonyms: Phosphatidylinositol 5-phosphate 4-kinase type-2 alpha (PIP4K2A); Recombinant Human Phosphatidylinositol 5-phosphate 4-kinase type-2 alpha (PIP4K2A); PIP4K2A recombinant protein

• Host: E Coli or Yeast or Baculovirus or Mammalian Cell
• Purity/Purification: Greater or equal to 85% purity as determined by SDS-PAGE.
• Form/Format: Lyophilized or liquid (Format to be determined during the manufacturing process)
• Sequence Positions: 2-406, Full length protein
• Sequence: ATPGNLGSSVLASKTKTKKKHFVAQKVKLFRASDPLLSVLMWGVNHSINELSHVQIPVMLMPDDFKAYSKIKVDNHLFNKENMPSHFKFKEYCPMVFRNLRERFGIDDQDFQNSLTRSAPLPNDSQARSGARFHTSYDKRYIIKTITSEDVAEMHNILKKYHQYIVECHGITLLPQFLGMYRLNVDGVEIYVIVTRNVFSHRLSVYRKYDLKGSTVAREASDKEKAKELPTLKDNDFINEGQKIYIDDNNKKVFLEKLKKDVEFLAQLKLMDYSLLVGIHDVERAEQEEVECEENDGEEEGESDGTHPVGTPPDSPGNTLNSSPPLAPGEFDPNIDVYGIKCHENSPRKEVYFMAIIDILTHYDAKKKAAHAAKTVKHGAGAEISTVNPEQYSKRFLDFIGHILT
• Sequence Length: 405

• Species: Human
• Preparation and Storage: Store at -20 degrees C. For long-term storage, store at -20 degrees C or -80 degrees C. Store working aliquots at 4 degrees C for up to one week. Repeated freezing and thawing is not recommended.

Related Product Information for PIP4K2A recombinant protein

Phosphatidylinositol-5,4-bisphosphate, the precursor to second messengers of the phosphoinositide signal transduction pathways, is thought to be involved in the regulation of secretion, cell proliferation, differentiation, and motility. This protein is one of a family of enzymes capable of catalyzing the phosphorylation of phosphatidylinositol-5-phosphate on the fourth hydroxyl of the myo-inositol ring to form phosphatidylinositol-5,4-bisphosphate. The amino acid sequence of this enzyme does not show homology to other kinases, but the recombinant protein does exhibit kinase activity. This gene is a member of the phosphatidylinositol-5-phosphate 4-kinase family.

NCBI and Uniprot Product Information

• NCBI GI #: 1052292374
• NCBI GeneID: 5305
• NCBI Accession #: NP_001316991.1
• NCBI GenBank Nucleotide #: NM_001330062.1
• UniProt Accession #: P48426; P53807; Q5VUX3; B0YJ66; B4DGX2; D3DRV1
• Molecular Weight: 39,802 Da
• NCBI Official Full Name: phosphatidylinositol 5-phosphate 4-kinase type-2 alpha isoform 2
• NCBI Official Synonym Full Names: phosphatidylinositol-5-phosphate 4-kinase type 2 alpha
• NCBI Official Symbol: PIP4K2A
• NCBI Official Synonym Symbols: PIPK; PI5P4KA; PIP5K2A; PIP5KIIA; PIP5KII-alpha
• NCBI Protein Information: phosphatidylinositol 5-phosphate 4-kinase type-2 alpha
• UniProt Protein Name: Phosphatidylinositol 5-phosphate 4-kinase type-2 alpha
• Protein Family: Phosphatidylinositol 5-phosphate 4-kinase
• UniProt Gene Name: PIP4K2A
• UniProt Synonym Gene Names: PIP5K2; PIP5K2A; PI(5)P 4-kinase type II alpha; PIP4KII-alpha

NCBI Description

Phosphatidylinositol-5,4-bisphosphate, the precursor to second messengers of the phosphoinositide signal transduction pathways, is thought to be involved in the regulation of secretion, cell proliferation, differentiation, and motility. The protein encoded by this gene is one of a family of enzymes capable of catalyzing the phosphorylation of phosphatidylinositol-5-phosphate on the fourth hydroxyl of the myo-inositol ring to form phosphatidylinositol-5,4-bisphosphate. The amino acid sequence of this enzyme does not show homology to other kinases, but the recombinant protein does exhibit kinase activity. This gene is a member of the phosphatidylinositol-5-phosphate 4-kinase family. [provided by RefSeq, Jul 2008]

Uniprot Description

Catalyzes the phosphorylation of phosphatidylinositol 5-phosphate (PtdIns5P) on the fourth hydroxyl of the myo-inositol ring, to form phosphatidylinositol 4,5-bisphosphate (PtdIns(4,5)P2). May exert its function by regulating the levels of PtdIns5P, which functions in the cytosol by increasing AKT activity and in the nucleus signals through ING2. May regulate the pool of cytosolic PtdIns5P in response to the activation of tyrosine phosphorylation. May negatively regulate insulin-stimulated glucose uptake by lowering the levels of PtdIns5P. May be involved in thrombopoiesis, and the terminal maturation of megakaryocytes and regulation of their size.