PIN2-Interacting Protein 1 Recombinant Protein | PINX1 recombinant protein
Recombinant Human PIN2-Interacting Protein 1
Gene Names
PINX1; LPTL; LPTS
Purity
Greater than 95.0% as determined by analysis by SDS-PAGE.
Synonyms
PIN2-Interacting Protein 1; Recombinant Human PIN2-Interacting Protein 1; PINX1 Human; PIN2-Interacting Protein 1 Human Recombinant; PINX1; LPTL; LPTS; MGC8850; FLJ20565; Pin2-interacting protein X1; TRF1-interacting protein 1; Liver-related putative tumor suppressor; Protein 67-11-3; PINX1 recombinant protein
Host
E Coli
Purity/Purification
Greater than 95.0% as determined by analysis by SDS-PAGE.
Form/Format
The PINX1 protein contains 20mM Tris-HCl buffer pH-8, 1mM DTT and 10% glycerol.
Sterile filtered colorless solution.
Sterile filtered colorless solution.
Sequence
MGSSHHHHHH SSGLVPRGSH MSMLAERRRK QKWAVDPQNT AWSNDDSKFG QRMLEKMGWS KGKGLGAQEH GATDHIKVQV KNNHLGLGAT INNEDNWIAH QDDFNQLLAE LNTCHGQETT DSSDKKEKKS FSLEEKSKIS KNRVHYMKFT KGKDLSSRSK TDLDCIFGKR QSKKTPEGDA SPSTPEENET TTTSAFTIQE YFAKRMAALK NKPQVPVPGS DISETQVERK RGKKINKEAT GKDVESYLQP KAKRHTEGKP ERAEAQERVA KKKSAPAEEQ LRGPCWDQSS KASAQDAGDH VQPPEGRDFT LKPKKRRGKK KLQKPVEIAE DATLEETLVK KKKKKDSK
Sequence Length
174
Preparation and Storage
Store at 4 degree C if entire vial will be used within 2-4 weeks. Store, frozen at -20 degree C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA). Avoid multiple freeze-thaw cycles.
Related Product Information for PINX1 recombinant protein
Description: Recombinant Human PINX1 produced in E Coli is a single, non-glycosylated polypeptide chain containing 348 amino acids (1-328 a.a) and having a molecular mass of 39.1 kDa. PINX1 is fused to 20 amino acid His Tag at N-terminus and purified by proprietary chromatographic techniques.
Introduction: PINX1 is a common expressed protein that localizes to nucleoli and telomere speckles. PINX1 contains a Telomerase Inhibiting Domain that is caable of binding MCRS1, TERT and TERF1. PINX1 has been shown to be a potent telomerase inhibitor and putative tumor suppressor. PINX1 is recruited to chromosome periphery by Nucleolin, their complex is necessary for faithful chromosome congression. PINX1 regulates the nucleolar accumulation and telomeric association of TRF1. PINX1 is involved in gastric cancer development. PINX1 expression is a sign of gastric cancer development. Constitutive expression of PINX1 attributes to telomere maintenance by telomerase and tumorigenicity in cancer cells.
Introduction: PINX1 is a common expressed protein that localizes to nucleoli and telomere speckles. PINX1 contains a Telomerase Inhibiting Domain that is caable of binding MCRS1, TERT and TERF1. PINX1 has been shown to be a potent telomerase inhibitor and putative tumor suppressor. PINX1 is recruited to chromosome periphery by Nucleolin, their complex is necessary for faithful chromosome congression. PINX1 regulates the nucleolar accumulation and telomeric association of TRF1. PINX1 is involved in gastric cancer development. PINX1 expression is a sign of gastric cancer development. Constitutive expression of PINX1 attributes to telomere maintenance by telomerase and tumorigenicity in cancer cells.
Product Categories/Family for PINX1 recombinant protein
NCBI and Uniprot Product Information
NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
Molecular Weight
19,714 Da
NCBI Official Full Name
PIN2/TERF1-interacting telomerase inhibitor 1 isoform 2
NCBI Official Synonym Full Names
PIN2/TERF1 interacting, telomerase inhibitor 1
NCBI Official Symbol
PINX1
NCBI Official Synonym Symbols
LPTL; LPTS
NCBI Protein Information
PIN2/TERF1-interacting telomerase inhibitor 1; 67-11-3 protein; PIN2 interacting protein 1; PIN2-interacting protein 1; TRF1-interacting protein 1; hepatocellular carcinoma-related putative tumor suppressor; liver-related putative tumor suppressor; pin2-interacting protein X1; protein 67-11-3
UniProt Protein Name
PIN2/TERF1-interacting telomerase inhibitor 1
Protein Family
UniProt Gene Name
PINX1
UniProt Synonym Gene Names
LPTL; LPTS
UniProt Entry Name
PINX1_HUMAN
Uniprot Description
PINX1: Microtubule-binding protein essential for faithful chromosome segregation. Mediates TRF1 and TERT accumulation in nucleolus and enhances TRF1 binding to telomeres. Inhibits telomerase activity. May inhibit cell proliferation and act as tumor suppressor. Belongs to the PINX1 family. 2 isoforms of the human protein are produced by alternative splicing.
Protein type: Tumor suppressor; Inhibitor; Nucleolus
Chromosomal Location of Human Ortholog: 8p23
Cellular Component: nucleoplasm; kinetochore; nuclear chromosome; chromosome, telomeric region; mitochondrion; intracellular membrane-bound organelle; cytoplasm; nucleolus; spindle; nucleus
Molecular Function: protein binding
Biological Process: negative regulation of cell proliferation; negative regulation of telomerase activity; regulation of telomerase activity; telomere maintenance via telomerase; mitotic metaphase plate congression
Research Articles on PINX1
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Product Notes
The PINX1 pinx1 (Catalog #AAA143904) is a Recombinant Protein produced from E Coli and is intended for research purposes only. The product is available for immediate purchase. The amino acid sequence is listed below: MGSSHHHHHH SSGLVPRGSH MSMLAERRRK QKWAVDPQNT AWSNDDSKFG QRMLEKMGWS KGKGLGAQEH GATDHIKVQV KNNHLGLGAT INNEDNWIAH QDDFNQLLAE LNTCHGQETT DSSDKKEKKS FSLEEKSKIS KNRVHYMKFT KGKDLSSRSK TDLDCIFGKR QSKKTPEGDA SPSTPEENET TTTSAFTIQE YFAKRMAALK NKPQVPVPGS DISETQVERK RGKKINKEAT GKDVESYLQP KAKRHTEGKP ERAEAQERVA KKKSAPAEEQ LRGPCWDQSS KASAQDAGDH VQPPEGRDFT LKPKKRRGKK KLQKPVEIAE DATLEETLVK KKKKKDSK. It is sometimes possible for the material contained within the vial of "PIN2-Interacting Protein 1, Recombinant Protein" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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