Mouse PTEN induced putative kinase 1 ELISA Kit | PINK1 elisa kit
Mouse Serine/threonine-protein kinase PINK1, mitochondrial, PINK1 ELISA Kit
NCBI and Uniprot Product Information
Uniprot Description
PINK1: Protects against mitochondrial dysfunction during cellular stress, potentially by phosphorylating mitochondrial proteins. Involved in the clearance of damaged mitochondria via selective autophagy (mitophagy). It is necessary for PARK2 recruitment to dysfunctional mitochondria to initiate their degradation. Interats with PARK2. Highly expressed in heart, skeletal muscle and testis, and at lower levels in brain, placenta, liver, kidney, pancreas, prostate, ovary and small intestine. Present in the embryonic testis from an early stage of development. Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. 2 isoforms of the human protein are produced by alternative splicing.
Protein type: Membrane protein, integral; Kinase, protein; Mitochondrial; Protein kinase, Other; Protein kinase, Ser/Thr (non-receptor); EC 2.7.11.1; Other group; NKF2 family
Cellular Component: mitochondrion; integral to membrane; mitochondrial intermembrane space; cytosol; mitochondrial outer membrane; cytoskeleton; membrane; perinuclear region of cytoplasm; axon; cytoplasm; mitochondrial inner membrane; TORC2 complex; nucleus; chromatin; integral to mitochondrial outer membrane
Molecular Function: transferase activity; protein kinase B binding; protein serine/threonine kinase activity; protease binding; metal ion binding; ubiquitin protein ligase binding; transferase activity, transferring phosphorus-containing groups; nucleotide binding; magnesium ion binding; kinase activity; ATP binding; protein kinase activity
Biological Process: positive regulation of dopamine secretion; positive regulation of translation; regulation of protein ubiquitination; protein ubiquitination; protein amino acid phosphorylation; positive regulation of protein amino acid dephosphorylation; negative regulation of macroautophagy; regulation of mitochondrial membrane potential; regulation of neuron apoptosis; response to stress; regulation of protein complex assembly; negative regulation of neuron apoptosis; regulation of hydrogen peroxide metabolic process; mitochondrion organization and biogenesis; positive regulation of I-kappaB kinase/NF-kappaB cascade; protein stabilization; positive regulation of synaptic transmission, dopaminergic; positive regulation of peptidyl-serine phosphorylation; peptidyl-serine phosphorylation; mitochondrion degradation; autophagy; positive regulation of catecholamine secretion; positive regulation of transcription factor activity; positive regulation of protein amino acid phosphorylation; response to oxidative stress; phosphorylation
Research Articles on PINK1
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Product Notes
The Mouse PINK1 pink1 (Catalog #AAA9337825) is an ELISA Kit and is intended for research purposes only. The product is available for immediate purchase. The AAA9337825 ELISA Kit recognizes Mouse PINK1. It is sometimes possible for the material contained within the vial of "PTEN induced putative kinase 1, ELISA Kit" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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