Mouse phosphoinositide-3-kinase, regulatory subunit 6 ELISA Kit | PIK3R6 elisa kit
Mouse Phosphoinositide 3-kinase regulatory subunit 6, PIK3R6 ELISA Kit
NCBI and Uniprot Product Information
NCBI Description
Phosphoinositide 3-kinase gamma is a lipid kinase that produces the lipid second messenger phosphatidylinositol 3,4,5-trisphosphate. The kinase is composed of a catalytic subunit and one of several regulatory subunits, and is chiefly activated by G protein-coupled receptors. This gene encodes a regulatory subunit, and is distantly related to the phosphoinositide-3-kinase, regulatory subunit 5 gene which is located adjacent to this gene on chromosome 11. The protein binds to both the catalytic subunit and to G(beta/gamma), and mediates activation of the kinase subunit downstream of G protein-coupled receptors. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
Uniprot Description
PIK3R6: Regulatory subunit of the PI3K gamma complex. Acts as an adapter to drive activation of PIK3CG by beta-gamma G protein dimers. The PIK3CG:PIK3R6 heterodimer is much less sensitive to beta-gamma G protein dimers than PIK3CG:PIK3R5 and its membrane recruitment and beta-gamma G protein dimer-dependent activation requires HRAS1 bound to PIK3CG. Recruits of the PI3K gamma complex to a PDE3B:RAPGEF3 signaling complex involved in angiogenesis; signaling seems to involve RRAS.
Cellular Component: membrane; cytoplasm
Molecular Function: phosphatidylinositol-4,5-bisphosphate 3-kinase activity; 1-phosphatidylinositol-3-kinase regulator activity
Biological Process: positive regulation of MAP kinase activity; G-protein coupled receptor protein signaling pathway; positive regulation of angiogenesis; angiogenesis; regulation of phosphoinositide 3-kinase activity
Research Articles on PIK3R6
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Product Notes
The Mouse PIK3R6 pik3r6 (Catalog #AAA9317602) is an ELISA Kit and is intended for research purposes only. The product is available for immediate purchase. The AAA9317602 ELISA Kit recognizes Mouse PIK3R6. It is sometimes possible for the material contained within the vial of "phosphoinositide-3-kinase, regulatory subunit 6, ELISA Kit" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
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