Human phosphatidylinositol glycan anchor biosynthesis, class M ELISA Kit | PIGM elisa kit
Human GPI mannosyltransferase 1, PIGM ELISA Kit
NCBI and Uniprot Product Information
NCBI Description
This gene encodes a transmembrane protein that is located in the endoplasmic reticulum and is involved in GPI-anchor biosynthesis. The glycosylphosphatidylinositol (GPI)-anchor is a glycolipid which contains three mannose molecules in its core backbone. The GPI-anchor is found on many blood cells and serves to anchor proteins to the cell surface. This gene encodes a mannosyltransferase, GPI-MT-I, that transfers the first mannose to GPI on the lumenal side of the endoplasmic reticulum. [provided by RefSeq, Jul 2008]
Uniprot Description
PIGM: Mannosyltransferase involved in glycosylphosphatidylinositol-anchor biosynthesis. Transfers the first alpha-1,4-mannose to GlcN-acyl-PI during GPI precursor assembly. Defects in PIGM are the cause of glycosylphosphatidylinositol deficiency (GPID). GPID is an autosomal recessive trait that results in a propensity to venous thrombosis and seizures. Deficiency is due to a point mutation in the regulatory sequences of PIGM that disrupts binding of the transcription factor SP1 to its cognate promoter motif, leading to a strong reduction of expression. Belongs to the PIGM family.
Protein type: Membrane protein, multi-pass; Membrane protein, integral; Glycan Metabolism - glycosylphosphatidylinositol (GPI)-anchor biosynthesis; Transferase; EC 2.4.1.-
Chromosomal Location of Human Ortholog: 1q23.2
Cellular Component: endoplasmic reticulum membrane; integral to membrane
Molecular Function: mannosyltransferase activity
Biological Process: cellular protein metabolic process; preassembly of GPI anchor in ER membrane; C-terminal protein lipidation; post-translational protein modification
Disease: Glycosylphosphatidylinositol Deficiency
Research Articles on PIGM
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Product Notes
The Human PIGM pigm (Catalog #AAA9340639) is an ELISA Kit and is intended for research purposes only. The product is available for immediate purchase. The AAA9340639 ELISA Kit recognizes Human PIGM. It is sometimes possible for the material contained within the vial of "phosphatidylinositol glycan anchor biosynthesis, class M, ELISA Kit" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
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