Pigeon Sorting Nexin 3 (SNX3) ELISA Kit | SNX3 elisa kit

Pigeon Sorting Nexin 3 (SNX3) ELISA Kit

• Gene Names: SNX3; SDP3; Grd19; MCOPS8
• Reactivity: Pigeon
• Synonyms: Sorting Nexin 3 (SNX3); Pigeon Sorting Nexin 3 (SNX3) ELISA Kit; SNX3 elisa kit

• Reactivity: Pigeon

• Preparation and Storage: Store all reagents at 2-8 degree C

NCBI and Uniprot Product Information

• NCBI GI #: 3127053
• NCBI GeneID: 8724
• Molecular Weight: 14,766 Da
• NCBI Official Full Name: sorting nexin 3
• NCBI Official Synonym Full Names: sorting nexin 3
• NCBI Official Symbol: SNX3
• NCBI Official Synonym Symbols: SDP3; Grd19; MCOPS8
• NCBI Protein Information: sorting nexin-3
• UniProt Protein Name: Sorting nexin-3
• Protein Family: Sorting nexin
• UniProt Gene Name: SNX3

NCBI Description

This gene encodes a member of the sorting nexin family. Members of this family contain a phox (PX) domain, which is a phosphoinositide binding domain, and are involved in intracellular trafficking. This protein does not contain a coiled coil region, like most family members. This protein interacts with phosphatidylinositol-3-phosphate, and is involved in protein trafficking. A pseudogene of this gene is present on the sex chromosomes. Alternative splicing results in multiple transcript variants encoding distinct isoforms. [provided by RefSeq, Jul 2014]

Uniprot Description

Phosphoinositide-binding protein required for multivesicular body formation. Specifically binds phosphatidylinositol 3-phosphate (PtdIns(P3)). Also can bind phosphatidylinositol 4-phosphate (PtdIns(P4)), phosphatidylinositol 5-phosphate (PtdIns(P5)) and phosphatidylinositol 3,5-biphosphate (PtdIns(3,5)P2) (). Plays a role in protein transport between cellular compartments. Together with RAB7A facilitates endosome membrane association of the retromer cargo-selective subcomplex (CSC/VPS). May in part act as component of the SNX3-retromer complex which mediates the retrograde endosome-to-TGN transport of WLS distinct from the SNX-BAR retromer pathway (PubMed:21725319, PubMed:24344282). Promotes stability and cell surface expression of epithelial sodium channel (ENAC) subunits SCNN1A and SCNN1G (). Not involved in EGFR degradation. Involved in the regulation of phagocytosis in dendritic cells possibly by regulating EEA1 recruitment to the nascent phagosomes (PubMed:23237080). Involved in iron homeostasis through regulation of endocytic recycling of the transferrin receptor TFRC presumably by delivering the transferrin:transferrin receptor complex to recycling endosomes; the function may involve the CSC retromer subcomplex (). In the case of Salmonella enterica infection plays arole in maturation of the Salmonella-containing vacuole (SCV) and promotes recruitment of LAMP1 to SCVs (PubMed:20482551).