Pigeon Sodium Channel Protein Type 5 Subunit Alpha (SCN5A) ELISA Kit | SCN5A elisa kit
Pigeon Sodium Channel Protein Type 5 Subunit Alpha (SCN5A) ELISA Kit
NCBI and Uniprot Product Information
NCBI Description
The protein encoded by this gene is an integral membrane protein and tetrodotoxin-resistant voltage-gated sodium channel subunit. This protein is found primarily in cardiac muscle and is responsible for the initial upstroke of the action potential in an electrocardiogram. Defects in this gene are a cause of long QT syndrome type 3 (LQT3), an autosomal dominant cardiac disease. Alternative splicing results in several transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008]
Uniprot Description
SCN5A: an integral membrane protein and a voltage-gated sodium channel subunit. Mediates the voltage-dependent sodium ion permeability of excitable membranes. This protein is found primarily in cardiac muscle and is responsible for the initial upstroke of the action potential in an electrocardiogram. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a sodium-selective channel through which Na(+) ions may pass in accordance with their electrochemical gradient. It is a tetrodotoxin-resistant Na(+) channel isoform. Intracellular calcium levels regulate channel inactivation. Interacts with the PDZ domain of the syntrophin SNTA1, SNTB1 and SNTB2. Interacts with NEDD4, NEDD4L, WWP2 and GPD1L. Defects in this protein are a cause of long QT syndrome type 3 (LQT3). Belongs to the sodium channel (TC 1.A.1.10) family, Nav1.5/SCN5A subfamily. 6 isoforms of the human protein are produced by alternative splicing.
Protein type: Channel, sodium; Membrane protein, integral; Membrane protein, multi-pass
Chromosomal Location of Human Ortholog: 3p22.2
Cellular Component: caveola; cell surface; endoplasmic reticulum; integral component of membrane; intercalated disc; intracellular; lateral plasma membrane; plasma membrane; sarcolemma; T-tubule; voltage-gated sodium channel complex; Z disc
Molecular Function: ankyrin binding; calmodulin binding; enzyme binding; fibroblast growth factor binding; ion channel binding; nitric-oxide synthase binding; protein binding; protein domain specific binding; protein kinase binding; ubiquitin protein ligase binding; voltage-gated ion channel activity; voltage-gated sodium channel activity; voltage-gated sodium channel activity involved in AV node cell action potential; voltage-gated sodium channel activity involved in bundle of His cell action potential; voltage-gated sodium channel activity involved in cardiac muscle cell action potential; voltage-gated sodium channel activity involved in Purkinje myocyte action potential; voltage-gated sodium channel activity involved in SA node cell action potential
Biological Process: atrial cardiac muscle cell action potential; AV node cell action potential; AV node cell to bundle of His cell communication; brainstem development; bundle of His cell action potential; cardiac muscle cell action potential involved in contraction; cardiac muscle contraction; cardiac ventricle development; cellular response to calcium ion; cerebellum development; generation of action potential; membrane depolarization; membrane depolarization during action potential; membrane depolarization during atrial cardiac muscle cell action potential; membrane depolarization during AV node cell action potential; membrane depolarization during bundle of His cell action potential; membrane depolarization during cardiac muscle cell action potential; membrane depolarization during Purkinje myocyte cell action potential; membrane depolarization during SA node cell action potential; odontogenesis of dentine-containing teeth; positive regulation of action potential; positive regulation of epithelial cell proliferation; positive regulation of sodium ion transport; regulation of cardiac muscle cell contraction; regulation of heart rate; regulation of heart rate by cardiac conduction; regulation of sodium ion transmembrane transport; response to denervation involved in regulation of muscle adaptation; SA node cell action potential; sodium ion transport; telencephalon development; ventricular cardiac muscle cell action potential
Disease: Atrial Fibrillation, Familial, 10; Brugada Syndrome 1; Cardiomyopathy, Dilated, 1e; Long Qt Syndrome 3; Progressive Familial Heart Block, Type Ia; Sick Sinus Syndrome 1, Autosomal Recessive; Sudden Infant Death Syndrome; Ventricular Fibrillation During Myocardial Infarction, Susceptibility To
Research Articles on SCN5A
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Product Notes
The Pigeon SCN5A scn5a (Catalog #AAA9904187) is an ELISA Kit and is intended for research purposes only. The product is available for immediate purchase. The AAA9904187 ELISA Kit recognizes Pigeon SCN5A. It is sometimes possible for the material contained within the vial of "Sodium Channel Protein Type 5 Subunit Alpha (SCN5A), ELISA Kit" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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