Pigeon Ras/Rap GTPase-Activating Protein SynGAP (SYNGAP1) ELISA Kit | SYNGAP1 elisa kit
Pigeon Ras/Rap GTPase-Activating Protein SynGAP (SYNGAP1) ELISA Kit
NCBI and Uniprot Product Information
NCBI Description
This gene encodes a Ras GTPase activating protein that is a member of the N-methyl-D-aspartate receptor complex. The N-terminal domain of the protein contains a Ras-GAP domain, a pleckstrin homology domain, and a C2 domain that may be involved in binding of calcium and phospholipids. The C-terminal domain consists of a ten histidine repeat region, serine and tyrosine phosphorylation sites, and a T/SXV motif required for postsynaptic scaffold protein interaction. The encoded protein negatively regulates Ras, Rap and alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid receptor trafficking to the postsynaptic membrane to regulate synaptic plasticity and neuronal homeostasis. Allelic variants of this gene are associated with intellectual disability and autism spectrum disorder. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Nov 2016]
Uniprot Description
SynGAP: an excitatory synapse-specific RasGAP. Member of the NMDAR signaling complex in excitatory synapses it may play a role in NMDAR-dependent control of AMPAR potentiation and synaptic plasticity. ERK activation is up-regulated in neurons from SynGAP knockout mice, whereas P38 MAPK function is depressed. May play a critical role in the regulation of neuronal MAPK signaling, AMPAR membrane trafficking, and excitatory synaptic transmission. Interacts with CAMK2A/CAMK2B and MPDZ. Phosphorylated by CaM-kinase II. Dephosphorylated upon NMDA receptor activation or SYNGAP1/MPDZ complex disruption. Contains a PH domain and a Ras-GAP domain. Two alternatively spliced isoforms have been described.
Protein type: GAP; GAP, Ras
Chromosomal Location of Human Ortholog: 6p21.32
Cellular Component: cytoplasm; cytosol; dendritic shaft; postsynaptic density
Molecular Function: GTPase activator activity; SH3 domain binding
Biological Process: dendrite development; MAPK cascade; negative regulation of axonogenesis; negative regulation of neuron apoptosis; negative regulation of Ras protein signal transduction; pattern specification process; positive regulation of GTPase activity; Ras protein signal transduction; receptor clustering; regulation of long-term neuronal synaptic plasticity; regulation of MAPK cascade; regulation of synapse structure or activity; regulation of synaptic plasticity; visual learning
Disease: Mental Retardation, Autosomal Dominant 5
Research Articles on SYNGAP1
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Product Notes
The Pigeon SYNGAP1 syngap1 (Catalog #AAA9905695) is an ELISA Kit and is intended for research purposes only. The product is available for immediate purchase. The AAA9905695 ELISA Kit recognizes Pigeon SYNGAP1. It is sometimes possible for the material contained within the vial of "Ras/Rap GTPase-Activating Protein SynGAP (SYNGAP1), ELISA Kit" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
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