Pigeon Dual Specificity Protein Phosphatase 10 (DUSP10) ELISA Kit | DUSP10 elisa kit
Pigeon Dual Specificity Protein Phosphatase 10 (DUSP10) ELISA Kit
NCBI and Uniprot Product Information
NCBI Description
Dual specificity protein phosphatases inactivate their target kinases by dephosphorylating both the phosphoserine/threonine and phosphotyrosine residues. They negatively regulate members of the MAP kinase superfamily, which is associated with cellular proliferation and differentiation. Different members of this family of dual specificity phosphatases show distinct substrate specificities for MAP kinases, different tissue distribution and subcellular localization, and different modes of expression induction by extracellular stimuli. This gene product binds to and inactivates p38 and SAPK/JNK. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Apr 2014]
Uniprot Description
DUSP10: a non-receptor, dual-specificity phosphoprotein phosphatase (DUSP). Different members of the DUSP family show distinct substrate specificities for MAPKs, different tissue distribution and subcellular localization, and different modes of induction by extracellular stimuli. Inactivates MAP kinases of the p38 and JNK subfamily, but not the ERK subfamily. Inhibits myogenesis and regeneration of skeletal muscle. It is evenly distributed in both the cytoplasm and the nucleus. Widely expressed in various tissues and organs, and its expression is elevated by stress stimuli. Inhibits intestinal epithelial cell growth. Mice deficient in expression of DUSP10 contained elevated levels of circulating IL-6 compared to wild type mice, apparently due to hyperphosphorylation of the DUSP10 substrate RAB3IL1. Elevated levels of expression in colorectal cancer patients were associated with improved survival probability. Two isoforms of the human protein are produced by alternative splicing.
Protein type: EC 3.1.3.16; EC 3.1.3.48; Motility/polarity/chemotaxis; Protein phosphatase, dual-specificity
Chromosomal Location of Human Ortholog: 1q41
Cellular Component: cytoplasm; cytosol; Golgi apparatus; nuclear speck; nucleoplasm; nucleus
Molecular Function: JUN kinase binding; MAP kinase phosphatase activity; MAP kinase tyrosine/serine/threonine phosphatase activity; mitogen-activated protein kinase p38 binding; phosphoprotein phosphatase activity; phosphoric monoester hydrolase activity; protein tyrosine phosphatase activity
Biological Process: dephosphorylation; inactivation of MAPK activity; negative regulation of cell migration; negative regulation of epithelial cell migration; negative regulation of epithelial cell proliferation; negative regulation of epithelium regeneration; negative regulation of ERK1 and ERK2 cascade; negative regulation of JNK activity; negative regulation of JNK cascade; negative regulation of oligodendrocyte differentiation; negative regulation of protein kinase activity by regulation of protein phosphorylation; negative regulation of stress-activated protein kinase signaling cascade; oligodendrocyte differentiation; peptidyl-threonine dephosphorylation; peptidyl-tyrosine dephosphorylation involved in inactivation of protein kinase activity; positive regulation of regulatory T cell differentiation; protein amino acid dephosphorylation; regulation of adaptive immune response; regulation of brown fat cell differentiation; response to lipopolysaccharide
Research Articles on DUSP10
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Product Notes
The Pigeon DUSP10 dusp10 (Catalog #AAA9905834) is an ELISA Kit and is intended for research purposes only. The product is available for immediate purchase. The AAA9905834 ELISA Kit recognizes Pigeon DUSP10. It is sometimes possible for the material contained within the vial of "Dual Specificity Protein Phosphatase 10 (DUSP10), ELISA Kit" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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