Mouse protein inhibitor of activated STAT, 2 ELISA Kit | PIAS2 elisa kit
Mouse E3 SUMO-protein ligase PIAS2, PIAS2 ELISA Kit
NCBI and Uniprot Product Information
Uniprot Description
PIAS2: Functions as an E3-type small ubiquitin-like modifier (SUMO) ligase, stabilizing the interaction between UBE2I and the substrate, and as a SUMO-tethering factor. Plays a crucial role as a transcriptional coregulator in various cellular pathways, including the STAT pathway, the p53 pathway and the steroid hormone signaling pathway. The effects of this transcriptional coregulation, transactivation or silencing may vary depending upon the biological context and the PIAS2 isoform studied. However, it seems to be mostly involved in gene silencing. Binds to sumoylated ELK1 and enhances its transcriptional activity by preventing recruitment of HDAC2 by ELK1, thus reversing SUMO-mediated repression of ELK1 transactivation activity. Isoform PIAS2-beta, but not isoform PIAS2-alpha, promotes MDM2 sumoylation. Isoform PIAS2-alpha promotes PARK7 sumoylation. Isoform PIAS2-beta promotes NCOA2 sumoylation more efficiently than isoform PIAS2- alpha. Belongs to the PIAS family. 3 isoforms of the human protein are produced by alternative splicing.
Protein type: Transcription, coactivator/corepressor; Nuclear receptor co-regulator; EC 6.3.2.-; SUMO conjugating system
Cellular Component: nuclear body; PML body; nucleus
Molecular Function: protein domain specific binding; zinc ion binding; coenzyme F420-2 alpha-glutamyl ligase activity; metal ion binding; ribosomal S6-glutamic acid ligase activity; transcription factor binding; SUMO ligase activity; protein binding; DNA binding; androgen receptor binding; ubiquitin protein ligase binding; UDP-N-acetylmuramoylalanyl-D-glutamyl-2,6-diaminopimelate-D-alanyl-D-alanine ligase activity; estrogen receptor binding; coenzyme F420-0 gamma-glutamyl ligase activity; glucocorticoid receptor binding; ligase activity
Biological Process: regulation of transcription from RNA polymerase II promoter; protein sumoylation; regulation of transcription, DNA-dependent; regulation of osteoblast differentiation; transcription, DNA-dependent; negative regulation of transcription factor activity; positive regulation of transcription, DNA-dependent; androgen receptor signaling pathway; positive regulation of transcription from RNA polymerase II promoter; positive regulation of dendrite morphogenesis
Research Articles on PIAS2
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Product Notes
The Mouse PIAS2 pias2 (Catalog #AAA9335157) is an ELISA Kit and is intended for research purposes only. The product is available for immediate purchase. The AAA9335157 ELISA Kit recognizes Mouse PIAS2. It is sometimes possible for the material contained within the vial of "protein inhibitor of activated STAT, 2, ELISA Kit" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
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