Hamster Prostaglandin E2 ELISA Kit | PGE2 elisa kit

Hamster Prostaglandin E2 ELISA Kit

Cat. Num. AAA45364

• Gene Names: PTGER4; EP4; EP4R
• Reactivity: Hamster
• Synonyms: Prostaglandin E2; Hamster Prostaglandin E2 ELISA Kit; PGE2 elisa kit

• Reactivity: Hamster
• Sequence Length: 488

• Samples: Undiluted original hamster serum, plasma or tissue homogenates samples
• Detection Range: 15.6pg/ml-500pg/ml
• Sensitivity: 5.0pg/ml
• Intra-assay Precision: Intra-assay CV (%) is less than 15%.
• Inter-assay Precision: Inter-assay CV (%) is less than 15%. [CV(%) = SD/mean ×100]. All CV% should be compared by concentration, not compared by OD values.
• Preparation and Storage: Store all reagents at 2-8 degree C

Typical Testing Data/Standard Curve (for reference only)

NCBI and Uniprot Product Information

• NCBI GI #: 4506259
• NCBI GeneID: 5734
• NCBI Accession #: NP_000949.1
• NCBI GenBank Nucleotide #: NM_000958.2
• UniProt Accession #: P35408; Q3MJ87
• Molecular Weight: 53,119 Da
• NCBI Official Full Name: prostaglandin E2 receptor EP4 subtype
• NCBI Official Synonym Full Names: prostaglandin E receptor 4 (subtype EP4)
• NCBI Official Symbol: PTGER4
• NCBI Official Synonym Symbols: EP4; EP4R
• NCBI Protein Information: prostaglandin E2 receptor EP4 subtype; prostanoid EP4 receptor; PGE receptor EP4 subtype; PGE receptor, EP4 subtype; PGE2 receptor EP4 subtype
• UniProt Protein Name: Prostaglandin E2 receptor EP4 subtype
• Protein Family: Prostaglandin E2 receptor
• UniProt Gene Name: PTGER4
• UniProt Synonym Gene Names: PTGER2; PGE receptor EP4 subtype
• UniProt Entry Name: PE2R4_HUMAN

NCBI Description

The protein encoded by this gene is a member of the G-protein coupled receptor family. This protein is one of four receptors identified for prostaglandin E2 (PGE2). This receptor can activate T-cell factor signaling. It has been shown to mediate PGE2 induced expression of early growth response 1 (EGR1), regulate the level and stability of cyclooxygenase-2 mRNA, and lead to the phosphorylation of glycogen synthase kinase-3. Knockout studies in mice suggest that this receptor may be involved in the neonatal adaptation of circulatory system, osteoporosis, as well as initiation of skin immune responses. [provided by RefSeq, Jul 2008]

Uniprot Description

PTGER4: Receptor for prostaglandin E2 (PGE2). The activity of this receptor is mediated by G(s) proteins that stimulate adenylate cyclase. Has a relaxing effect on smooth muscle. May play an important role in regulating renal hemodynamics, intestinal epithelial transport, adrenal aldosterone secretion, and uterine function. Belongs to the G-protein coupled receptor 1 family.

Protein type: Receptor, GPCR; Membrane protein, integral; GPCR, family 1; Membrane protein, multi-pass

Chromosomal Location of Human Ortholog: 5p13.1

Cellular Component: plasma membrane; integral to membrane

Molecular Function: protein binding; prostaglandin E receptor activity

Biological Process: G-protein signaling, coupled to cAMP nucleotide second messenger; response to mechanical stimulus; T-helper cell differentiation; regulation of stress fiber formation; negative regulation of inflammatory response; negative regulation of cytokine secretion; JNK cascade; response to lipopolysaccharide; immune response; negative regulation of integrin activation; regulation of ossification; positive regulation of inflammatory response; positive regulation of cytokine secretion