Pepsin A-3/PGI/PGA3 Recombinant Protein | LOC101929842 recombinant protein

Recombinant Human Pepsin A-3/PGI/PGA3 protein, C-His Tag

Cat. Num. AAA157987

• Purity: >90% as determined by SDS-PAGE
• Synonyms: Pepsin A-3/PGI/PGA3; Recombinant Human Pepsin A-3/PGI/PGA3 protein; C-His Tag; LOC101929842 recombinant protein

• Host: Mammalian cells
• Purity/Purification: >90% as determined by SDS-PAGE
• Form/Format: Lyophilized. Lyophilized from PBS pH 7.4, 5% Trehalose, 5% Mannose, 1mM EDTA.

• Species: Human
• Endotoxin level: <1.0EU per ug of the protein as determined by the LAL method
• Reconstitution: Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details
• Construction: A DNA sequence encoding the human PGA3 (Met1~Ala388) was fused with the C-terminal His Tag
• Preparation and Storage: Store at 2 to 8 degree C for one week. Store at -20 to -80 degree C for twelve months from the date of receipt. Use a manual defrost freezer and avoid repeated freeze thaw cycles.; Shipping: In general, proteins are provided as lyophilized powder/frozen liquid.

SDS-Page

Product Categories/Family for LOC101929842 recombinant protein

Other proteins; IVD material

NCBI and Uniprot Product Information

• NCBI GI #: 378521956
• NCBI GeneID: 101929842
• UniProt Accession #: P0DJD8; P00790; Q7M4R0; Q8N1E3; A8K749; B2R7D6; B7ZW75
• Molecular Weight: 388
• NCBI Official Full Name: Pepsin A-3
• NCBI Official Symbol: LOC101929842
• NCBI Protein Information: pepsin A-3-like
• UniProt Protein Name: Pepsin A-3
• UniProt Gene Name: PGA3
• UniProt Entry Name: PEPA3_HUMAN

NCBI Description

This gene encodes a protein precursor of the digestive enzyme pepsin, a member of the peptidase A1 family of endopeptidases. The encoded precursor is secreted by gastric chief cells and undergoes autocatalytic cleavage in acidic conditions to form the active enzyme, which functions in the digestion of dietary proteins. This gene is found in a cluster of related genes on chromosome 11, each of which encodes one of multiple pepsinogens. Pepsinogen levels in serum may serve as a biomarker for atrophic gastritis and gastric cancer. [provided by RefSeq, Jul 2015]

Uniprot Description

PGA3: Shows particularly broad specificity; although bonds involving phenylalanine and leucine are preferred, many others are also cleaved to some extent. Belongs to the peptidase A1 family.

Protein type: EC 3.4.23.1; Secreted, signal peptide; Secreted

Chromosomal Location of Human Ortholog: 11q12.2

Molecular Function: aspartic-type endopeptidase activity

Biological Process: digestion; proteolysis