NCBI and Uniprot Product Information
NCBI Description
binds actin; regulates the rate of actin polymerization [RGD, Feb 2006]
Uniprot Description
profilin 2: Binds to actin and affects the structure of the cytoskeleton. At high concentrations, profilin prevents the polymerization of actin, whereas it enhances it at low concentrations. By binding to PIP2, it inhibits the formation of IP3 and DG. Belongs to the profilin family. 2 isoforms of the human protein are produced by alternative splicing.
Protein type: Motility/polarity/chemotaxis; Actin-binding
Cellular Component: cytoplasm; cytoskeleton; terminal button
Molecular Function: actin binding; actin monomer binding; adenyl-nucleotide exchange factor activity; phosphatidylinositol-4,5-bisphosphate binding
Biological Process: actin cytoskeleton organization and biogenesis; negative regulation of actin filament polymerization; positive regulation of actin filament bundle formation; positive regulation of actin filament polymerization; positive regulation of ATPase activity; positive regulation of peptidyl-serine phosphorylation; positive regulation of stress fiber formation; protein stabilization; regulation of actin filament polymerization
Research Articles on Pfn2
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Product Notes
The Rat Pfn2 pfn2 (Catalog #AAA289818) is an ELISA Kit and is intended for research purposes only. The product is available for immediate purchase. The AAA289818 ELISA Kit recognizes Rat Pfn2. It is sometimes possible for the material contained within the vial of "Profilin-2, ELISA Kit" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
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