Rat 6-phosphofructokinase ELISA Kit | Pfkl elisa kit
Rat 6-phosphofructokinase, liver type ELISA Kit
NCBI and Uniprot Product Information
NCBI Description
catalyses the synthesis and degradation of Fru-2;6-P2; mediates switching mechanism in glycolysis/gluconeogenesis opposing fluxes [RGD, Feb 2006]
Uniprot Description
PFKL: phosphofructokinase, liver type. An ubiquitous metabolic enzyme involved in the synthesis and degradation of fructose 2,6-bisphosphate. Key control step of glycolysis. An allosteric enzyme activated by ADP, AMP, or fructose bisphosphate and inhibited by ATP or citrate. Activity: ATP D-fructose 6-phosphate = ADP D-fructose 1,6-bisphosphate. The holoenzyme consists of 4 subunits. The liver and muscle enzymes are homo-tetramers of four liver or muscle isoforms, respectively. The red blood cell enzyme consists hetero-tetramers of the muscle and liver isoforms. A subunit composition with a higher proportion of platelet type subunits is found in platelets, brain and fibroblasts. Two alternatively spliced isoforms have been described.
Protein type: Carbohydrate Metabolism - fructose and mannose; Carbohydrate Metabolism - galactose; Carbohydrate Metabolism - glycolysis and gluconeogenesis; Carbohydrate Metabolism - pentose phosphate pathway; EC 2.7.1.11; Kinase, other
Chromosomal Location of Human Ortholog: 20p12
Cellular Component: 6-phosphofructokinase complex; cytosol; membrane
Molecular Function: 6-phosphofructokinase activity; ATP binding; fructose-2,6-bisphosphate 2-phosphatase activity; identical protein binding; kinase binding; monosaccharide binding
Biological Process: carbohydrate metabolic process; fructose 1,6-bisphosphate metabolic process; fructose 6-phosphate metabolic process; glycolysis; negative regulation of insulin secretion; protein homotetramerization; protein oligomerization; response to glucose stimulus
Research Articles on Pfkl
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Product Notes
The Rat Pfkl pfkl (Catalog #AAA9426405) is an ELISA Kit and is intended for research purposes only. The product is available for immediate purchase. The AAA9426405 ELISA Kit recognizes Rat Pfkl. It is sometimes possible for the material contained within the vial of "6-phosphofructokinase, ELISA Kit" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
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