Phosphoinositide 3 Kinase, SH3 Binding Peptide | pik3r1-a peptide
Phosphoinositide 3 Kinase, SH3 Binding Peptide (PI3K)
Gene Names
pik3r1-a; pik3r1
Purity
Highly Purified~90% by HPLC and MS analysis
Synonyms
Phosphoinositide 3 Kinase; SH3 Binding Peptide; SH3 Binding Peptide (PI3K); pik3r1-a peptide
Purity/Purification
Highly Purified
~90% by HPLC and MS analysis
~90% by HPLC and MS analysis
Form/Format
Supplied as a lyophilized powder.
Sequence (linear)
H2N-Arg-Lys-Leu-Pro-Pro-Arg-Pro-Arg-Arg-OH
Phosphoinositide 3 kinase (PI3K) is a kinase catalyzing the phosphorylation of PI(4,5)P2 at the D3 position of the inositol ring. The resulting product PI(3,4,5)P3 can be recognized by PH domain-containing signaling molecules, including various kinases and their regulators, and activates the corresponding cell signaling pathways, eventually leading to cell growth, survival and cellular movement (1). PI3K is a heterodimer with a p85 regulatory subunit and p110 catalytic subunit. The p85 subunit has two SH2 domains binding to phospho-tyrosine with the consensus motif (Y*XXM) where X denotes any amino acid and Y* is phosphorylated tyrosine. This motif exists in many of the receptor tyrosine kinases and their substrates, such as EGFR, FGFR, IRS-1, BCAP and GAB1 (2,3). The docking of PI3K in the membrane vicinity through p85 recognization of the phosphorylated YXXM in signaling molecules activates the PI3K pathway. Phospho-(Tyr) p85 PI3K Binding Motif Antibody specifically recognizes PI3K binding targets at their phosphorylated YXXM motif, providing a powerful new tool for PI3K binding protein discovery and characterization as well as HTS drug screening for potential regulators.
Phosphoinositide 3 kinase (PI3K) is a kinase catalyzing the phosphorylation of PI(4,5)P2 at the D3 position of the inositol ring. The resulting product PI(3,4,5)P3 can be recognized by PH domain-containing signaling molecules, including various kinases and their regulators, and activates the corresponding cell signaling pathways, eventually leading to cell growth, survival and cellular movement (1). PI3K is a heterodimer with a p85 regulatory subunit and p110 catalytic subunit. The p85 subunit has two SH2 domains binding to phospho-tyrosine with the consensus motif (Y*XXM) where X denotes any amino acid and Y* is phosphorylated tyrosine. This motif exists in many of the receptor tyrosine kinases and their substrates, such as EGFR, FGFR, IRS-1, BCAP and GAB1 (2,3). The docking of PI3K in the membrane vicinity through p85 recognization of the phosphorylated YXXM in signaling molecules activates the PI3K pathway. Phospho-(Tyr) p85 PI3K Binding Motif Antibody specifically recognizes PI3K binding targets at their phosphorylated YXXM motif, providing a powerful new tool for PI3K binding protein discovery and characterization as well as HTS drug screening for potential regulators.
Amino Acid Analysis
Confirms expected sequence
Peptide Content: 81.2 ± 4%
Peptide Content: 81.2 ± 4%
Solubility
H2O
Preparation and Storage
Lyophilized powder may be stored at 4 degree C for short-term only. Stable for 12 months at -20 degree C. Reconstitute to nominal volume (see reconstitution instructions for peptides) and store at -20 degree C. For maximum recovery of product, centrifuge the original vial prior to removing the cap. Further dilutions can be made in assay buffer.
Related Product Information for pik3r1-a peptide
Selective phosphoinositol 3-kinase SH3 ligand
Product Categories/Family for pik3r1-a peptide
NCBI and Uniprot Product Information
NCBI GI #
NCBI GeneID
UniProt Accession #
Molecular Weight
1174
NCBI Official Full Name
phosphoinositide-3-kinase
NCBI Official Symbol
pik3r1-a
NCBI Official Synonym Symbols
pik3r1
NCBI Protein Information
phosphatidylinositol 3-kinase regulatory subunit alpha; ptdIns-3-kinase p85-alpha; PI3-kinase p85 subunit alpha; PI3-kinase subunit p85-alpha; PI3K regulatory subunit alpha; PI3-kinase regulatory subunit alpha; ptdIns-3-kinase regulatory subunit alpha; ptdIns-3-kinase regulatory subunit p85-alpha; phosphatidylinositol 3-kinase 85 kDa regulatory subunit alpha
UniProt Protein Name
Phosphatidylinositol 3-kinase regulatory subunit alpha
UniProt Gene Name
pik3r1-a
UniProt Synonym Gene Names
PI3-kinase regulatory subunit alpha; PI3K regulatory subunit alpha; PtdIns-3-kinase regulatory subunit alpha; PI3-kinase subunit p85-alpha
UniProt Entry Name
P85AA_XENLA
Uniprot Description
Function: Binds to activated (phosphorylated) protein-Tyr kinases, through its SH2 domain, and acts as an adapter, mediating the association of the p110 catalytic unit to the plasma membrane
By similarity.
Subunit structure: Heterodimer of a p110 (catalytic) and a p85 (regulatory) subunits
By similarity.
Sequence similarities: Belongs to the PI3K p85 subunit family.Contains 1 Rho-GAP domain.Contains 2 SH2 domains.Contains 1 SH3 domain.
Research Articles on pik3r1-a
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Product Notes
The pik3r1-a pik3r1-a (Catalog #AAA659865) is a Peptide and is intended for research purposes only. The product is available for immediate purchase. It is sometimes possible for the material contained within the vial of "Phosphoinositide 3 Kinase, SH3 Binding Peptide, Peptide" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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