Rat PDZ domain containing 1 ELISA Kit | PDZK1 elisa kit

Rat Na (+) /H (+) exchange regulatory cofactor NHE-RF3

Cat. Num. AAA9325823

• Reactivity: Rat
• Synonyms: PDZ domain containing 1; Rat Na (+) /H (+) exchange regulatory cofactor NHE-RF3; Rat Na (+) /H (+) exchange regulatory cofactor NHE-RF3 (PDZK1) ELISA kit; CAP70; CLAMP; NHERF3; PDZD1; C-terminal linking and modulating protein; OTTHUMP00000015572; PDZK1 elisa kit

• Reactivity: Rat

• Preparation and Storage: Store all reagents at 2-8 degree C

NCBI and Uniprot Product Information

• NCBI GI #: 126723666
• NCBI GeneID: 100008900
• NCBI Accession #: NP_001075620.1
• NCBI GenBank Nucleotide #: NM_001082151.2
• UniProt Accession #: Q865P3
• Molecular Weight: 56,972 Da
• NCBI Official Full Name: Na(+)/H(+) exchange regulatory cofactor NHE-RF3
• NCBI Official Symbol: PDZK1
• NCBI Protein Information: Na(+)/H(+) exchange regulatory cofactor NHE-RF3; Na(+)/H(+) exchange regulatory cofactor NHE-RF3; NHERF-3; PDZK1-like protein; PDZ domain-containing protein 1; CFTR-associated protein of 70 kDa; Na(+)/H(+) exchanger regulatory factor 3; sodium-hydrogen exchanger regulatory factor 3
• UniProt Protein Name: Na(+)/H(+) exchange regulatory cofactor NHE-RF3
• Protein Family: Na(+)/H(+) exchange regulatory cofactor
• UniProt Gene Name: PDZK1
• UniProt Synonym Gene Names: CAP70; NHERF3; NHERF-3
• UniProt Entry Name: NHRF3_RABIT

Uniprot Description

Function: A scaffold protein that connects plasma membrane proteins and regulatory components, regulating their surface expression in epithelial cells apical domains. May be involved in the coordination of a diverse range of regulatory processes for ion transport and second messenger cascades. In complex with SLC9A3R1, may cluster proteins that are functionally dependent in a mutual fashion and modulate the trafficking and the activity of the associated membrane proteins. May play a role in the cellular mechanisms associated with multidrug resistance through its interaction with ABCC2 and PDZK1IP1. May potentiate the CFTR chloride channel activity. Required for normal cell-surface expression of SCARB1. Plays a role in maintaining normal plasma cholesterol levels via its effects on SCARB1. Plays a role in the normal localization and function of the chloride-anion exchanger SLC26A6 to the plasma membrane in the brush border of the proximal tubule of the kidney. May be involved in the regulation of proximal tubular Na+-dependent inorganic phosphate cotransport therefore playing an important role in tubule function 1 PublicationManual assertion based on experiment in:Ref.1