Rat PDS5, regulator of cohesion maintenance, homolog B (S. cerevisiae) ELISA Kit | PDS5B elisa kit
Rat Sister chromatid cohesion protein PDS5 homolog B, PDS5B ELISA Kit
NCBI and Uniprot Product Information
Uniprot Description
APRIN: a widely expressed nuclear protein. Is lost in many cancers and may function as a tumor suppressor. Correlates with differentiation in embryonal carcinoma stem cells; its knockdown disrupted Nanog, Oct4, and SOX2 regulation. Plays a role in androgen-induced proliferative arrest in prostate cells. Is upregulated in androgen-sensitive LNCaP prostate cancer cells undergoing androgen-induced proliferative block. Required for maintenance of sister chromatid cohesion during mitosis. May couple sister chromatid cohesion during mitosis to DNA replication. Cohesion ensures that chromosome partitioning is accurate in both meiotic and mitotic cells and plays an important role in DNA repair. Belongs to the PDS5 family. Induced by the synthetic androgen R1881 in prostate carcinoma cells undergoing proliferative arrest. Phosphorylated upon DNA damage. Maximum levels occur 18-20 hours after androgen exposure. Interacts with the cohesin complex. Phosphorylated upon DNA damage, probably by ATM or ATR. Five isoforms of the human protein are produced by alternative splicing.
Protein type: DNA-binding; Cell development/differentiation
Cellular Component: nucleoplasm; nucleus; chromatin
Molecular Function: DNA binding
Biological Process: negative regulation of cell proliferation; cell division; mitotic sister chromatid cohesion; regulation of cell proliferation
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Product Notes
The Rat PDS5B pds5b (Catalog #AAA9331746) is an ELISA Kit and is intended for research purposes only. The product is available for immediate purchase. The AAA9331746 ELISA Kit recognizes Rat PDS5B. It is sometimes possible for the material contained within the vial of "PDS5, regulator of cohesion maintenance, homolog B (S. cerevisiae), ELISA Kit" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
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