ERp72 recombinant protein
ERp72 (human), (recombinant) (His-tag)
Gene Names
PDIA4; ERP70; ERP72; ERp-72
Applications
Western Blot
Purity
>=85% (SDS-PAGE; Western blot)Purified by multi-step chromatography
Synonyms
ERp72; ERp72 (human); (recombinant) (His-tag); ERp72 recombinant protein
Host
E Coli
Purity/Purification
>=85% (SDS-PAGE; Western blot)
Purified by multi-step chromatography
Purified by multi-step chromatography
Form/Format
Liquid. In 50mM TRIS, pH7.5, containing 150mM sodium chloride and 1mM EDTA
Applicable Applications for ERp72 recombinant protein
Western Blot (WB), Activity assay
Application Notes
Activity Assay: >90U/mg
WB: 25ng, colorimetric
WB: 25ng, colorimetric
Source Note
Human ERp72 is fused at the N-terminus to a His-tag
Preparation and Storage
For long term storage, store at -80 degree C
Shipping: Shipped on Dry Ice
Shipping: Shipped on Dry Ice
Related Product Information for ERp72 recombinant protein
Endoplasmic reticulum protein (ERp) 72 is a member of the protein disulfide isomerase (PDI) family that is localized to the endoplasmic reticulum. It contains three repeats of the thioredoxin-like regions that is postulated to represent three independently acting catalytic domains (CGHC) of PDI activity. ERp72 contains the sequence at its carboxyl terminus which serves as its ER retention signal. Together with other ER resident proteins such as BiP, GRP94, and PDI, they serve as the molecular chaperones for proper folding of newly translocated and glycolsylated proteins such as thyroglobulin (Tg) and human chorionic gonadotropin (hCG)-b. ERp72 expression is regulated by the level of misfolding proteins in the ER, as the amount of ERp72 increased in response to epithelial ischemia, a condition that perturbs the maturation of secretory proteins.
Product Categories/Family for ERp72 recombinant protein
NCBI and Uniprot Product Information
NCBI GI #
NCBI GeneID
Molecular Weight
645
NCBI Official Full Name
Protein disulfide-isomerase A4
NCBI Official Synonym Full Names
protein disulfide isomerase family A, member 4
NCBI Official Symbol
PDIA4
NCBI Official Synonym Symbols
ERP70; ERP72; ERp-72
NCBI Protein Information
protein disulfide-isomerase A4; ER protein 70; ER protein 72; protein disulfide isomerase-associated 4; endoplasmic reticulum resident protein 70; endoplasmic reticulum resident protein 72; protein disulfide isomerase related protein (calcium-binding prot
UniProt Protein Name
Protein disulfide-isomerase A4
UniProt Gene Name
PDIA4
UniProt Synonym Gene Names
ERP70; ERP72; ER protein 70; ERp70; ER protein 72; ERp-72; ERp72
UniProt Entry Name
PDIA4_HUMAN
Uniprot Description
PDIA4: Part a large chaperone multiprotein complex comprising DNAJB11, HSP90B1, HSPA5, HYOU, PDIA2, PDIA4, PDIA6, PPIB, SDF2L1, UGT1A1 and very small amounts of ERP29, but not, or at very low levels, CALR nor CANX. Belongs to the protein disulfide isomerase family.
Protein type: EC 5.3.4.1; Isomerase; Chaperone; Endoplasmic reticulum
Chromosomal Location of Human Ortholog: 7q35
Cellular Component: cell surface; endoplasmic reticulum; endoplasmic reticulum lumen; melanosome
Molecular Function: protein binding; protein disulfide isomerase activity
Biological Process: protein folding; cell redox homeostasis; protein secretion
Research Articles on ERp72
Similar Products
Product Notes
The ERp72 pdia4 (Catalog #AAA565957) is a Recombinant Protein produced from E Coli and is intended for research purposes only. The product is available for immediate purchase. AAA Biotech's ERp72 can be used in a range of immunoassay formats including, but not limited to, Western Blot (WB), Activity assay. Activity Assay: >90U/mg WB: 25ng, colorimetric. Researchers should empirically determine the suitability of the ERp72 pdia4 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "ERp72, Recombinant Protein" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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