ERP72 Recombinant Protein | PDIA4 recombinant protein

ERP72 Protein, Human, Recombinant (hFc Tag)

Cat. Num. AAA8121380

• Gene Names: PDIA4; ERP70; ERP72; ERp-72
• Purity: >90% as determined by SDS-PAGE
• Synonyms: ERP72; ERP72 Protein; Human; Recombinant (hFc Tag); Human ERP72/PDIA4 Protein (Fc Tag); ERp-72 Protein; ERP70 Protein; protein disulfide isomerase family A; member 4; PDIA4 recombinant protein

• Host: HEK293 Cells
• Purity/Purification: >90% as determined by SDS-PAGE
• Form/Format: Lyophilized from sterile PBS, pH7.4. Normally 5%-8% trehalose, mannitol and 0.01% Tween80 are added as protectants before lyophilization. Please refer to the specific buffer information in the hard copy of CoA.
• Sequence: Met1-Thr641

• Species: Human
• Endotoxin: <1.0EU per ug of the protein as determined by the LAL method
• Predicted N Terminal: Val 21
• Tag: C-human IgG1-Fc
• Protein Construction: A DNA sequence encoding the human PDIA4 (P13667)(Met1-Thr641) was expressed, fused with the Fc region of human IgG1 at the C-terminus.
• Reconstitution: A hardcopy of COA with reconstitution instruction is sent along with the products. Please refer to it for detailed information.
• Preparation and Storage: Samples are stable for up to twelve months from date of receipt at -20 degree C to -80 degree C. Store it under sterile conditions at -20 degree C to -80 degree C. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.; In general, recombinant proteins are provided as lyophilized powder which are shipped at ambient temperature. Bulk packages of recombinant proteins are provided as frozen liquid.; They are shipped out with blue ice.

SDS-Page

Related Product Information for PDIA4 recombinant protein

Background: ERP72, also known as PDIA4, is an endoplasmic reticulum luminal protein which belongs to the protein disulfide isomerase family. ERP72 is a stress protein and participates in the catalysis of protein-S-S-bond rearrangement. Both PDIA4 and PDIA3 function as proteases, protein disulfide isomerases, phospholipases or an arrangement of these. ERP72 compose part of a large chaperone multiprotein complex comprising CABP1, DNAJB11, HSP90B1, HSPA5, HYOU, PDIA2, PDIA4, PPIB, SDF2L1, UGT1A1 and very small amounts of ERP29, but not, or at very low levels, CALR nor CANX.

References

Tsai YC, et al. (2012) Functional proteomics establishes the interaction of SIRT7 with chromatin remodeling complexes and expands its role in regulation of RNA polymerase I transcription. Mol Cell Proteomics. 11(5):60-76.Kim W, et al. (2011) Systematic and quantitative assessment of the ubiquitin-modified proteome. Mol Cell. 44(2):325-40.Vinayagam A, et al. (2011) A directed protein interaction network for investigating intracellular signal transduction. Sci Signal. 4(189):rs8.

NCBI and Uniprot Product Information

• NCBI GI #: 119530
• NCBI GeneID: 9601
• UniProt Accession #: P13667; Q549T6; A8K4K6
• Molecular Weight: 645
• NCBI Official Full Name: Protein disulfide-isomerase A4
• NCBI Official Synonym Full Names: protein disulfide isomerase family A, member 4
• NCBI Official Symbol: PDIA4
• NCBI Official Synonym Symbols: ERP70; ERP72; ERp-72
• NCBI Protein Information: protein disulfide-isomerase A4; ER protein 70; ER protein 72; protein disulfide isomerase-associated 4; endoplasmic reticulum resident protein 70; endoplasmic reticulum resident protein 72; protein disulfide isomerase related protein (calcium-binding prot
• UniProt Protein Name: Protein disulfide-isomerase A4
• Protein Family: Protein disulfide-isomerase
• UniProt Gene Name: PDIA4
• UniProt Synonym Gene Names: ERP70; ERP72; ER protein 70; ERp70; ER protein 72; ERp-72; ERp72
• UniProt Entry Name: PDIA4_HUMAN

Uniprot Description

PDIA4: Part a large chaperone multiprotein complex comprising DNAJB11, HSP90B1, HSPA5, HYOU, PDIA2, PDIA4, PDIA6, PPIB, SDF2L1, UGT1A1 and very small amounts of ERP29, but not, or at very low levels, CALR nor CANX. Belongs to the protein disulfide isomerase family.

Protein type: EC 5.3.4.1; Isomerase; Chaperone; Endoplasmic reticulum

Chromosomal Location of Human Ortholog: 7q35

Cellular Component: cell surface; endoplasmic reticulum; endoplasmic reticulum lumen; melanosome

Molecular Function: protein binding; protein disulfide isomerase activity

Biological Process: protein folding; cell redox homeostasis; protein secretion