Typical Testing Data/Standard Curve (for reference only)
Mouse platelet-derived growth factor receptor, beta polypeptide ELISA Kit | PDGFRB elisa kit
Mouse Beta-type platelet-derived growth factor receptor, PDGFRB ELISA Kit
Typical Testing Data/Standard Curve (for reference only)
Typical Testing Data/Standard Curve (for reference only)
NCBI and Uniprot Product Information
Uniprot Description
PDGFRB: a receptor tyrosine kinase of the PDGFR family that binds members of the platelet-derived growth factor family. The identity of the growth factor bound determines whether the functional receptor is a homodimer or a heterodimer, composed of both PDGFR-alpha and -beta. Ligand binding induces receptor dimerization and autophosphorylation, thereby recruiting SH2-containing proteins including Grb2, Src, GAP, PTPN11, PI3 kinase, PLC-gamma and Nck. Regulates cell growth, actin reorganization, migration and differentiation. A variety of myeloproliferative disorders and cancers result from translocations that activate PDGFRbeta by fusion with proteins such as TEL/ETV6, H2, CEV14/TRP11, rabaptin 5, and huntington interacting protein 1. Gleevec treatment of TEL fusions has been successful. Overexpressed in metastatic medulloblastoma. Inhibitors: Gleevec, Sutent.
Protein type: Membrane protein, integral; EC 2.7.10.1; Protein kinase, tyrosine (receptor); Oncoprotein; Protein kinase, TK; Kinase, protein; TK group; PDGFR family
Cellular Component: cell surface; focal adhesion; membrane; lysosome; cytoplasm; apical plasma membrane; integral to membrane; plasma membrane; cytoplasmic vesicle; nucleus; intrinsic to plasma membrane
Molecular Function: platelet-derived growth factor binding; nucleotide binding; platelet-derived growth factor receptor binding; platelet-derived growth factor receptor activity; transmembrane receptor protein tyrosine kinase activity; protein kinase binding; protein kinase activity; transferase activity; protein binding; signal transducer activity; protein-tyrosine kinase activity; platelet-derived growth factor beta-receptor activity; transferase activity, transferring phosphorus-containing groups; phosphoinositide 3-kinase binding; kinase activity; ATP binding; receptor binding
Biological Process: positive regulation of phosphoprotein phosphatase activity; peptidyl-tyrosine phosphorylation; positive regulation of smooth muscle cell proliferation; multicellular organismal development; protein amino acid autophosphorylation; positive regulation of collagen biosynthetic process; platelet-derived growth factor receptor signaling pathway; cardiac myofibril assembly; chemotaxis; signal transduction; positive regulation of smooth muscle cell migration; protein amino acid phosphorylation; smooth muscle development; positive regulation of MAP kinase activity; nitrogen compound metabolic process; positive regulation of cell proliferation; tissue homeostasis; hemopoiesis; phosphatidylinositol metabolic process; kidney development; regulation of peptidyl-tyrosine phosphorylation; cell migration; phosphoinositide-mediated signaling; positive regulation of mitosis; adrenal gland development; in utero embryonic development; positive regulation of chemotaxis; positive regulation of phosphoinositide 3-kinase activity; positive regulation of phosphoinositide 3-kinase cascade; glycosaminoglycan biosynthetic process; skeletal morphogenesis; regulation of actin cytoskeleton organization and biogenesis; phosphorylation; transmembrane receptor protein tyrosine kinase signaling pathway; negative regulation of apoptosis; positive regulation of cell migration
Research Articles on PDGFRB
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Product Notes
The Mouse PDGFRB pdgfrb (Catalog #AAA919047) is an ELISA Kit and is intended for research purposes only. The product is available for immediate purchase. The AAA919047 ELISA Kit recognizes Mouse PDGFRB. It is sometimes possible for the material contained within the vial of "platelet-derived growth factor receptor, beta polypeptide, ELISA Kit" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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