Human proprotein convertase subtilisin/kexin type 6 ELISA Kit | PCSK6 elisa kit
Human Proprotein convertase subtilisin/kexin type 6, PCSK6 ELISA Kit
NCBI and Uniprot Product Information
NCBI Description
This gene encodes a member of the subtilisin-like proprotein convertase family, which includes proteases that process protein and peptide precursors trafficking through regulated or constitutive branches of the secretory pathway. The encoded protein undergoes an initial autocatalytic processing event in the ER to generate a heterodimer which exits the ER and sorts to the trans-Golgi network where a second autocatalytic event takes place and the catalytic activity is acquired. The encoded protease is constitutively secreted into the extracellular matrix and expressed in many tissues, including neuroendocrine, liver, gut, and brain. This gene encodes one of the seven basic amino acid-specific members which cleave their substrates at single or paired basic residues. Some of its substrates include transforming growth factor beta related proteins, proalbumin, and von Willebrand factor. This gene is thought to play a role in tumor progression and left-right patterning. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Feb 2014]
Uniprot Description
PCSK6: Likely to represent an endoprotease activity within the constitutive secretory pathway, with unique restricted distribution in both neuroendocrine and non-neuroendocrine tissues and capable of cleavage at the RX(K/R)R consensus motif. Belongs to the peptidase S8 family. 8 isoforms of the human protein are produced by alternative splicing.
Protein type: Secreted; Protease; Secreted, signal peptide; EC 3.4.21.-
Chromosomal Location of Human Ortholog: 15q26.3
Cellular Component: extracellular matrix; extracellular space; cell surface; membrane; Golgi lumen; endoplasmic reticulum
Molecular Function: heparin binding; serine-type endopeptidase activity; endopeptidase activity; nerve growth factor binding
Biological Process: nerve growth factor processing; zygotic determination of anterior/posterior axis, embryo; nerve growth factor receptor signaling pathway; glycoprotein metabolic process; regulation of BMP signaling pathway; peptide hormone processing; protein processing; proteolysis; determination of left/right symmetry; nerve growth factor production; secretion by cell
Research Articles on PCSK6
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Product Notes
The Human PCSK6 pcsk6 (Catalog #AAA9323189) is an ELISA Kit and is intended for research purposes only. The product is available for immediate purchase. The AAA9323189 ELISA Kit recognizes Human PCSK6. It is sometimes possible for the material contained within the vial of "proprotein convertase subtilisin/kexin type 6, ELISA Kit" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
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