Phosphoenolpyruvate carboxykinase [GTP], mitochondrial (PCK2) Recombinant Protein | PCK2 recombinant protein

Recombinant Human Phosphoenolpyruvate carboxykinase [GTP], mitochondrial (PCK2)

Cat. Num. AAA1361813

• Gene Names: PCK2; PEPCK; PEPCK2; PEPCK-M
• Purity: Greater or equal to 85% purity as determined by SDS-PAGE.
• Synonyms: Phosphoenolpyruvate carboxykinase [GTP]; mitochondrial (PCK2); Recombinant Human Phosphoenolpyruvate carboxykinase [GTP]; PCK2 recombinant protein

• Host: E Coli or Yeast or Baculovirus or Mammalian Cell
• Purity/Purification: Greater or equal to 85% purity as determined by SDS-PAGE.
• Form/Format: Lyophilized or liquid (Format to be determined during the manufacturing process)
• Sequence Positions: 33-640, Full length protein
• Sequence: LSGDLGQLPTGIRDFVEHSARLCQPEGIHICDGTEAENTATLTLLEQQGLIRKLPKYNNCWLARTDPKDVARVESKTVIVTPSQRDTVQLPPGGARGQLGNWMSPADFQRAVDERFPGCMQGRTMYVLPFSMGPVGSPLSRIGVQLTDSAYVVASMRIMTRLGTPVLQALGDGDFVKCLHSVGQPLTGQGEPVSQWPCNPEKTLIGHVPDQREIISFGSGYGGNSLLGKKCFALRIASRLARDEGWLAEHMLILGITSPAGKKRYVAAAFPSACGKTNLAMMRPALPGWKVECVGDDIAWMRFDSEGRLRAINPENGFFGVAPGTSATTNPNAMATIQSNTIFTNVAETSDGGVYWEGIDQPLPPGVTVTSWLGKPWKPGDKEPCAHPNSRFCAPARQCPIMDPAWEAPEGVPIDAIIFGGRRPKGVPLVYEAFNWRHGVFVGSAMRSESTAAAEHKGKIIMHDPFAMRPFFGYNFGHYLEHWLSMEGRKGAQLPRIFHVNWFRRDEAGHFLWPGFGENARVLDWICRRLEGEDSARETPIGLVPKEGALDLSGLRAIDTTQLFSLPKDFWEQEVRDIRSYLTEQVNQDLPKEVLAELEALERRVHKM
• Sequence Length: 608

• Species: Human
• Preparation and Storage: Store at -20 degrees C. For long-term storage, store at -20 degrees C or -80 degrees C. Store working aliquots at 4 degrees C for up to one week. Repeated freezing and thawing is not recommended.

Related Product Information for PCK2 recombinant protein

This gene encodes a member of the phosphoenolpyruvate carboxykinase (GTP) family. The protein is a mitochondrial enzyme that catalyzes the conversion of oxaloacetate to phosphoenolpyruvate in the presence of GTP. A cytosolic form encoded by a different gene has also been characterized and is the key enzyme of gluconeogenesis in the liver. The encoded protein may serve a similar function, although it is constitutively expressed and not modulated by hormones such as glucagon and insulin that regulate the cytosolic form. Alternatively spliced transcript variants have been described.

NCBI and Uniprot Product Information

• NCBI GI #: 614458223
• NCBI GeneID: 5106
• NCBI Accession #: NP_001018083.2
• NCBI GenBank Nucleotide #: NM_001018073.2
• UniProt Accession #: Q16822; O43253; Q86U01; Q9BV62
• Molecular Weight: 47,564 Da
• NCBI Official Full Name: phosphoenolpyruvate carboxykinase
• NCBI Official Synonym Full Names: phosphoenolpyruvate carboxykinase 2, mitochondrial
• NCBI Official Symbol: PCK2
• NCBI Official Synonym Symbols: PEPCK; PEPCK2; PEPCK-M
• NCBI Protein Information: phosphoenolpyruvate carboxykinase [GTP], mitochondrial
• UniProt Protein Name: Phosphoenolpyruvate carboxykinase [GTP], mitochondrial
• Protein Family: Protein kinase
• UniProt Gene Name: PCK2
• UniProt Synonym Gene Names: PEPCK2; PEPCK-M

NCBI Description

This gene encodes a mitochondrial enzyme that catalyzes the conversion of oxaloacetate to phosphoenolpyruvate in the presence of guanosine triphosphate (GTP). A cytosolic form of this protein is encoded by a different gene and is the key enzyme of gluconeogenesis in the liver. Alternatively spliced transcript variants have been described. [provided by RefSeq, Apr 2014]

Uniprot Description

Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP), the rate-limiting step in the metabolic pathway that produces glucose from lactate and other precursors derived from the citric acid cycle.