PARVA recombinant protein

Recombinant Human PARVA Protein

Cat. Num. AAA8249545

• Gene Names: PARVA; MXRA2; CH-ILKBP
• Reactivity: Human
• Applications: ELISA, Western Blot, SDS-Page
• Purity: Greater than 95% as determined by reducing SDS-PAGE.
• Synonyms: PARVA; Recombinant Human PARVA Protein; MXRA2; Alpha-parvin; Actopaxin; CH-ILKBP; Calponin-like integrin-linked kinase-binding protein; Matrix-remodeling-associated protein 2; PARVA recombinant protein

• Host: E Coli
• Reactivity: Human
• Purity/Purification: Greater than 95% as determined by reducing SDS-PAGE.
• Form/Format: Supplied as a 0.2 muM filtered solution of 50mM Tris, 150mM NaCl, 40% Glycerol, pH 7.4.
• Sequence: MATSPQKSPS APKSPTPKSP PSRKKDDSFL GKLGGTLARR KKAKEVSELQ EEGMNAINLP LSPIPFELDP EDTMLEENEV RTMVDPNSRS DPKLQELMKV LIDWINDVLV GERIIVKDLA EDLYDGQVLQ KLFEKLESEK LNVAEVTQSE IAQKQKLQTV LEKINETLKL PPRSIKWNVD SVHAKSLVAI LHLLVALSQY FRAPIRLPDH VSIQVVVVQK REGILQSRQI QEEITGNTEA LSGRHERDAF DTLFDHAPDK LNVVKKTLIT FVNKHLNKLN LEVTELETQF ADGVYLVLLM GLLEGYFVPL HSFFLTPDSF EQKVLNVSFA FELMQDGGLE KPKPRPEDIV NCDLKSTLRV LYNLFTKYRN VELEHHHHHH
• Sequence Length: 412

• Applicable Applications for PARVA recombinant protein: ELISA (EIA),Western Blot (WB), SDS-PAGE, Mass Spectrometry (MS)
• Endotoxin: Less than 0.1 ng/mug (1 IEU/mug) as determined by LAL test.
• Directions for Use: Always centrifuge tubes before opening. Do not mix by vortex or pipetting. It is not recommended to reconstitute to a concentration less than 100 mug/ml. Dissolve the lyophilized protein in 1X PBS. Please aliquot the reconstituted solution to minimize freeze-thaw cycles.
• Preparation and Storage: Lyophilized protein should be stored at -20 degree C, though stable at room temperature for 3 weeks. Reconstituted protein solution can be stored at 2-8 degree C for 2-7 days. Aliquots of reconstituted samples are stable at -20 degree C for 3 months.

Related Product Information for PARVA recombinant protein

Recombinant Human PARVA Protein is produced by our E Coli expression system and the target gene encoding Met1-Glu372 is expressed with a 6His tag at the C-terminus.

NCBI and Uniprot Product Information

• NCBI GI #: 315583337
• NCBI GeneID: 55742
• NCBI Accession #: NP_060692.2
• NCBI GenBank Nucleotide #: NM_018222.4
• UniProt Accession #: Q9NVD7; Q96C85; Q9HA48
• Molecular Weight: 20,625 Da
• NCBI Official Full Name: alpha-parvin
• NCBI Official Synonym Full Names: parvin alpha
• NCBI Official Symbol: PARVA
• NCBI Official Synonym Symbols: MXRA2; CH-ILKBP
• NCBI Protein Information: alpha-parvin
• UniProt Protein Name: Alpha-parvin
• Protein Family: Parvalbumin
• UniProt Gene Name: PARVA
• UniProt Synonym Gene Names: MXRA2
• UniProt Entry Name: PARVA_HUMAN

NCBI Description

This gene encodes a member of the parvin family of actin-binding proteins. Parvins are associated with focal contacts and contain calponin homology domains that bind to actin filaments. The encoded protein is part of the integrin-linked kinase signaling complex and plays a role in cell adhesion, motility and survival. [provided by RefSeq, Dec 2010]

Uniprot Description

PARVA: Probably plays a role in the regulation of cell adhesion and cytoskeleton organization. Plays a role in ciliogenesis. Interacts with TGFB1I1. Interacts with integrin-linked protein kinase and probably with actin and the LD1 and LD4 motifs of PXN. Interacts with ARHGAP31. Widely expressed, with highest levels in heart, skeletal muscle, kidney and liver. Belongs to the parvin family. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Adaptor/scaffold; Motility/polarity/chemotaxis

Chromosomal Location of Human Ortholog: 11p15.3

Cellular Component: cell-cell adherens junction; cytosol; focal adhesion

Molecular Function: protein binding

Biological Process: establishment and/or maintenance of cell polarity; heterotypic cell-cell adhesion; sprouting angiogenesis