Rat par-6 partitioning defective 6 homolog alpha (C. elegans) ELISA Kit | PARD6A elisa kit
Rat Partitioning defective 6 homolog alpha, PARD6A ELISA Kit
NCBI and Uniprot Product Information
NCBI Description
The protein encoded by this gene is a component of the partitioning defective complex, a protein complex involved in controlling epithelial cell polarity as well as other cell processes. In rat testis cells, the protein localizes to the apical ectoplasmic specialization at the Sertoli-elongating spermatid interface and at the blood-testis barrier. Accordingly, knockdown of this gene in Sertoli cell epithelia results in compromised blood-testis barrier integrity. Knockdown of this gene in various neuronal cell types results in a variety of phenotypes including abnormal dendritic spine morphogenesis and defective axon outgrowth to the spinal midline. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Mar 2015]
Uniprot Description
PARD6A: Adapter protein involved in asymmetrical cell division and cell polarization processes. Probably involved in the formation of epithelial tight junctions. Association with PARD3 may prevent the interaction of PARD3 with F11R/JAM1, thereby preventing tight junction assembly. The PARD6-PARD3 complex links GTP-bound Rho small GTPases to atypical protein kinase C proteins. Interacts with MAP2K5. Interacts with PARD3. Interacts with GTP-bound forms of CDC42, ARHQ/TC10 and RAC1. Interacts with the N-terminal part of PRKCI and PRKCZ. Part of a complex with PARD3, CDC42 or RAC1 and PRKCI or PRKCZ. Part of a complex with LLGL1 and PRKCI. Interacts with human T-cell leukemia virus type I TAX protein. Interacts with MPP5 and CRB3. Interacts with TGFBR1; involved in TGF-beta induced epithelial to mesenchymal transition. Interacts with ECT2 ('Thr- 359' phosphorylated form) and PRKCI. Expressed in pancreas, skeletal muscle, brain and heart. Weakly expressed in kidney and placenta. Belongs to the PAR6 family. 2 isoforms of the human protein are produced by alternative splicing.
Protein type: Adaptor/scaffold; Cell adhesion; Motility/polarity/chemotaxis
Cellular Component: protein complex; tight junction; cell soma; apical part of cell; cytoplasm; plasma membrane; cell cortex; nucleus
Molecular Function: protein binding; Rho GTPase binding; protein kinase C binding; GTP-dependent protein binding
Biological Process: negative regulation of protein amino acid phosphorylation; cell division; intercellular junction maintenance
Research Articles on PARD6A
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Product Notes
The Rat PARD6A pard6a (Catalog #AAA9332150) is an ELISA Kit and is intended for research purposes only. The product is available for immediate purchase. The AAA9332150 ELISA Kit recognizes Rat PARD6A. It is sometimes possible for the material contained within the vial of "par-6 partitioning defective 6 homolog alpha (C. elegans), ELISA Kit" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
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