Pregnancy-Associated Plasma Protein-1 Recombinant Protein | PAPP-A recombinant protein
Recombinant Human Pregnancy-Associated Plasma Protein-1
Gene Names
PAPPA; PAPA; DIPLA1; PAPP-A; PAPPA1; ASBABP2; IGFBP-4ase
Purity
Greater than 95.0% as determined by SDS-PAGE.
Synonyms
Pregnancy-Associated Plasma Protein-1; Recombinant Human Pregnancy-Associated Plasma Protein-1; PAPP A Human; Pregnancy-Associated Plasma Protein-1 Human Recombinant; Pappalysin-1; Pregnancy-associated plasma protein A; PAPP-A; Insulin-like growth factor-dependent IGF-binding protein 4 protease; IGF-dependent IGFBP-4 protease; IGFBP-4ase; PAPPA; PAPA; DIPLA1; PAPPA1; ASBABP2; PAPP-A recombinant protein
Host
E Coli
Purity/Purification
Greater than 95.0% as determined by SDS-PAGE.
Form/Format
PAPP-A protein is supplied in 1x PBS and 50% glycerol.
Sterile Filtered clear solution.
Sterile Filtered clear solution.
Sequence Length
1627
Preparation and Storage
Store at 4 degree C if entire vial will be used within 2-4 weeks. Store, frozen at -20 degree C for longer periods of time. Please avoid freeze thaw cycles.
Related Product Information for PAPP-A recombinant protein
Description: PAPP-A Human Recombinant produced in E Coli is single, a non-glycosylated, Polypeptide chain containing 191 amino acids fragment (81-271) corresponding to the PAPP-A œJelly-Roll domain fragment, having a total molecular mass of 30kDa and fused with a 4.5kDa amino-terminal hexahistidine tag. The PAPP-A is purified by proprietary chromatographic techniques.
Introduction: PAPPA is a large zinc binding protein, which acts as a metalloprotease and specifically cleaves IGFBP-4 and IGFBP-5, resulting in release of bound IGF. PAPP-A can also act as a regulator of IGF bioactivity in a number of biological systems, including the human ovary and cardiovascular systems. It was shown that PAPP A levels are elevated in patients with unstable angina or acute myocardial infarction. Furthermore, PAPPA is believed to be involved in local proliferative processes such as wound healing and bone remodeling. Moreover, PAPP-A is produced in high concentrations during pregnancy and is released into the maternal circulation. In placenta, PAPP A is expressed in X cells in septa and anchoring villi, and in syncytiotrophoblasts in the chorionic villi. Lower levels of PAPPA are found in an array of other tissues including kidney, myometrium, endometrium, ovaries, breast, prostate, bone marrow, colon, fibroblasts and osteoblasts. PAPP-A is present in serum and placenta during pregnancy; with levels increasing throughout pregnancy. Low levels of PAPP A are associated with a number of foetal chromosomal abnormalities, as well as pre-eclampsia and stillbirth.PAPPA levels may be a potentially highly specific marker for heart disease.PAPP-A proteolytic activity is inhibited by targeting substrate exosite binding.
Introduction: PAPPA is a large zinc binding protein, which acts as a metalloprotease and specifically cleaves IGFBP-4 and IGFBP-5, resulting in release of bound IGF. PAPP-A can also act as a regulator of IGF bioactivity in a number of biological systems, including the human ovary and cardiovascular systems. It was shown that PAPP A levels are elevated in patients with unstable angina or acute myocardial infarction. Furthermore, PAPPA is believed to be involved in local proliferative processes such as wound healing and bone remodeling. Moreover, PAPP-A is produced in high concentrations during pregnancy and is released into the maternal circulation. In placenta, PAPP A is expressed in X cells in septa and anchoring villi, and in syncytiotrophoblasts in the chorionic villi. Lower levels of PAPPA are found in an array of other tissues including kidney, myometrium, endometrium, ovaries, breast, prostate, bone marrow, colon, fibroblasts and osteoblasts. PAPP-A is present in serum and placenta during pregnancy; with levels increasing throughout pregnancy. Low levels of PAPP A are associated with a number of foetal chromosomal abnormalities, as well as pre-eclampsia and stillbirth.PAPPA levels may be a potentially highly specific marker for heart disease.PAPP-A proteolytic activity is inhibited by targeting substrate exosite binding.
Product Categories/Family for PAPP-A recombinant protein
NCBI and Uniprot Product Information
NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
Molecular Weight
180,973 Da
NCBI Official Full Name
pappalysin-1 preproprotein
NCBI Official Synonym Full Names
pregnancy-associated plasma protein A, pappalysin 1
NCBI Official Symbol
PAPPA
NCBI Official Synonym Symbols
PAPA; DIPLA1; PAPP-A; PAPPA1; ASBABP2; IGFBP-4ase
NCBI Protein Information
pappalysin-1; IGF-dependent IGFBP-4 protease; aspecific BCL2 ARE-binding protein 2; differentially placenta 1 expressed protein; insulin-like growth factor-dependent IGF binding protein-4 protease; insulin-like growth factor-dependent IGF-binding protein 4 protease; pregnacy-associated plasma protein A
UniProt Protein Name
Pappalysin-1
UniProt Gene Name
PAPPA
UniProt Synonym Gene Names
IGF-dependent IGFBP-4 protease; IGFBP-4ase; PAPP-A
UniProt Entry Name
PAPP1_HUMAN
NCBI Description
This gene encodes a secreted metalloproteinase which cleaves insulin-like growth factor binding proteins (IGFBPs). It is thought to be involved in local proliferative processes such as wound healing and bone remodeling. Low plasma level of this protein has been suggested as a biochemical marker for pregnancies with aneuploid fetuses. [provided by RefSeq, Jul 2008]
Uniprot Description
PAPPA: Metalloproteinase which specifically cleaves IGFBP-4 and IGFBP-5, resulting in release of bound IGF. Cleavage of IGFBP-4 is dramatically enhanced by the presence of IGF, whereas cleavage of IGFBP-5 is slightly inhibited by the presence of IGF. Belongs to the peptidase M43B family.
Protein type: Secreted; Protease; EC 3.4.24.79; Secreted, signal peptide
Chromosomal Location of Human Ortholog: 9q33.2
Cellular Component: membrane; extracellular region
Molecular Function: zinc ion binding; metallopeptidase activity; metalloendopeptidase activity
Biological Process: cellular protein metabolic process; female pregnancy; cell differentiation; proteolysis
Research Articles on PAPP-A
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Product Notes
The PAPP-A pappa (Catalog #AAA143544) is a Recombinant Protein produced from E Coli and is intended for research purposes only. The product is available for immediate purchase. It is sometimes possible for the material contained within the vial of "Pregnancy-Associated Plasma Protein-1, Recombinant Protein" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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