Uniprot Description
PAOX: Flavoenzyme which catalyzes the oxidation of N(1)- acetylspermine to spermidine and is thus involved in the polyamine back-conversion. Can also oxidize N(1)-acetylspermidine to putrescine. Substrate specificity: N(1)-acetylspermine = N(1)- acetylspermidine > N(1),N(12)-diacylspermine >> spermine. Does not oxidize spermidine. Plays an important role in the regulation of polyamine intracellular concentration and has the potential to act as a determinant of cellular sensitivity to the antitumor polyamine analogs. Belongs to the flavin monoamine oxidase family. 11 isoforms of the human protein are produced by alternative splicing.
Protein type: EC 1.5.3.13; Oxidoreductase
Chromosomal Location of Human Ortholog: 10q26.3
Cellular Component: peroxisomal matrix
Molecular Function: receptor binding; polyamine oxidase activity
Biological Process: spermine catabolic process; polyamine biosynthetic process; putrescine biosynthetic process; xenobiotic metabolic process; spermidine catabolic process; polyamine catabolic process; putrescine catabolic process; polyamine metabolic process
Product Notes
The Human PAOX paox (Catalog #
AAA9334914) is an ELISA Kit and is intended for research purposes only. The product is available for immediate purchase. The AAA9334914 ELISA Kit recognizes Human PAOX.
It is sometimes possible for the material contained within the vial of
"polyamine oxidase (exo-N4-amino), ELISA Kit" to become dispersed throughout the inside of
the vial, particularly around the seal of said vial, during shipment and storage. We always
suggest centrifuging these vials
to consolidate all of the liquid away from the lid and to the bottom of the vial prior to
opening. Please be advised that
certain products may require dry ice for shipping and that, if this is the case, an
additional dry ice fee may also be
required.
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absolutely not suitable for use in any
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product from AAA Biotech, you
are explicitly certifying that said products will be properly tested and used in line with
industry standard. AAA Biotech
and its authorized distribution partners reserve the right to refuse to fulfill any order if
we have any indication that a
purchaser may be intending to use a product outside of our accepted criteria.
Disclaimer
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responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any
aspect of this datasheet at
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