PAXIP1-associated protein 1 (PA1) Recombinant Protein | PA1 recombinant protein

Recombinant Human PAXIP1-associated protein 1 (PA1)

Cat. Num. AAA1282089

• Gene Names: PAGR1; GAS; PA1; C16orf53
• Purity: Greater or equal to 85% purity as determined by SDS-PAGE.
• Synonyms: PAXIP1-associated protein 1 (PA1); Recombinant Human PAXIP1-associated protein 1 (PA1); PA1 recombinant protein

• Host: E Coli or Yeast or Baculovirus or Mammalian Cell
• Purity/Purification: Greater or equal to 85% purity as determined by SDS-PAGE.
• Form/Format: Lyophilized or liquid (Format to be determined during the manufacturing process)
• Sequence Positions: 1-254, Full length protein
• Sequence: MSLARGHGDTAASTAAPLSEEGEVTSGLQALAVEDTGGPSASAGKAEDEGEGGREETEREGSGGEEAQGEVPSAGGEEPAEEDSEDWCVPCSDEEVELPADGQPWMPPPSEIQRLYELLAAHGTLELQAEILPRRPPTPEAQSEEERSDEEPEAKEEEEEKPHMPTEFDFDDEPVTPKDSLIDRRRTPGSSARSQKREARLDKVLSDMKRHKKLEEQILRTGRDLFSLDSEDPSPASPPLRSSGSSLFPRQRKY
• Sequence Length: 254

• Species: Human
• Preparation and Storage: Store at -20 degrees C. For long-term storage, store at -20 degrees C or -80 degrees C. Store working aliquots at 4 degrees C for up to one week. Repeated freezing and thawing is not recommended.

NCBI and Uniprot Product Information

• NCBI GI #: 13375654
• NCBI GeneID: 79447
• NCBI Accession #: NP_078792.1
• NCBI GenBank Nucleotide #: NM_024516.3
• UniProt Accession #: Q9BTK6; A2ICR6
• Molecular Weight: 27,716 Da
• NCBI Official Full Name: PAXIP1-associated glutamate-rich protein 1
• NCBI Official Synonym Full Names: PAXIP1 associated glutamate rich protein 1
• NCBI Official Symbol: PAGR1
• NCBI Official Synonym Symbols: GAS; PA1; C16orf53
• NCBI Protein Information: PAXIP1-associated glutamate-rich protein 1
• UniProt Protein Name: PAXIP1-associated glutamate-rich protein 1
• UniProt Gene Name: PAGR1
• UniProt Synonym Gene Names: C16orf53; PA1; GAS

NCBI Description

C16ORF53 (PA1) is a component of a Set1-like multiprotein histone methyltransferase complex (Cho et al., 2007 [PubMed 17500065]).[supplied by OMIM, May 2008]

Uniprot Description

Its association with the histone methyltransferase MLL2/MLL3 complex is suggesting a role in epigenetic transcriptional activation. However, in association with PAXIP1/PTIP is proposed to function at least in part independently of the MLL2/MLL3 complex. Proposed to be recruited by PAXIP1 to sites of DNA damage where the PAGR1:PAXIP1 complex is required for cell survival in response to DNA damage independently of the MLL2/MLL3 complex (PubMed:19124460). However, its function in DNA damage has been questioned (). During immunoglobulin class switching in activated B-cells is involved in transcription regulation of downstream switch regions at the immunoglobulin heavy-chain (Igh) locus independently of the MLL2/MLL3 complex (). Involved in both estrogen receptor-regulated gene transcription and estrogen-stimulated G1/S cell-cycle transition (PubMed:19039327). Acts as transcriptional cofactor for nuclear hormone receptors. Inhibits the induction properties of several steroid receptors such as NR3C1, AR and PPARG; the mechanism of inhibition appears to be gene-dependent (PubMed:23161582).