Protein-Arginine Deiminase Type-4/PADI4 Recombinant Protein | PADI4 recombinant protein

Recombinant Human Protein-Arginine Deiminase Type-4/PADI4 Protein (N-6His)

Cat. Num. AAA2553159

• Gene Names: PADI4; PAD; PAD4; PDI4; PDI5; PADI5
• Purity: >95% as determined by reducing SDS-PAGE.
• Synonyms: Protein-Arginine Deiminase Type-4/PADI4; Recombinant Human Protein-Arginine Deiminase Type-4/PADI4 Protein (N-6His); Protein-Arginine Deiminase Type-4; HL-60 PAD; Peptidylarginine Deiminase IV; Protein-arginine Deiminase type IV; PADI4; PADI5; PDI5; PADI4 recombinant protein

• Host: E Coli
• Purity/Purification: >95% as determined by reducing SDS-PAGE.
• Form/Format: Supplied as a 0.2 mum filtered solution of 50mM Tris, 500mM NaCl, pH 7.5.
• Sequence Positions: Met1-Pro663
• Sequence Length: 663

• Species: Human
• Endotoxin: <1.0 EU per ug as determined by LAL test.
• Fusion Tag: N-6His
• Preparation and Storage: Store at < -20 degree C, stable for 6 months after receipt. Please minimize freeze-thaw cycles.

Related Product Information for PADI4 recombinant protein

Protein-Arginine Deiminase Type-4 (PADI4) belongs to the Protein Arginine Deiminase family. PADI4 is expressed in eosinophils and neutrophils, but it is not expressed in peripheral monocytes or lymphocytes. PADI4 catalyzes the citrullination/deimination of arginine residues of proteins. In addition, PADI4 may play an important role in tumourigenesis. Genetic variations in PADI4 are a cause of susceptibility to rheumatoid arthritis (RA), which is a systemic inflammatory disease with autoimmune features and a complex genetic component.

NCBI and Uniprot Product Information

• NCBI GI #: 216548487
• NCBI GeneID: 23569
• NCBI Accession #: NP_036519.2
• NCBI GenBank Nucleotide #: NM_012387.2
• UniProt Accession #: Q9UM07; Q5VTZ8; Q70SX4; A8K392; B2RBW0
• Molecular Weight: Molecular Mass: 76.2 kDa; Actual Protein Molecular Mass: 78 kDa
• NCBI Official Full Name: protein-arginine deiminase type-4
• NCBI Official Synonym Full Names: peptidyl arginine deiminase 4
• NCBI Official Symbol: PADI4
• NCBI Official Synonym Symbols: PAD; PAD4; PDI4; PDI5; PADI5
• NCBI Protein Information: protein-arginine deiminase type-4
• UniProt Protein Name: Protein-arginine deiminase type-4
• Protein Family: Protein-arginine deiminase
• UniProt Gene Name: PADI4
• UniProt Synonym Gene Names: PAD4; PADI5; PDI5

NCBI Description

This gene is a member of a gene family which encodes enzymes responsible for the conversion of arginine residues to citrulline residues. This gene may play a role in granulocyte and macrophage development leading to inflammation and immune response. [provided by RefSeq, Jul 2008]

Uniprot Description

Catalyzes the citrullination/deimination of arginine residues of proteins such as histones, thereby playing a key role in histone code and regulation of stem cell maintenance. Citrullinates histone H1 at 'Arg-54' (to form H1R54ci), histone H3 at 'Arg-2', 'Arg-8', 'Arg-17' and/or 'Arg-26' (to form H3R2ci, H3R8ci, H3R17ci, H3R26ci, respectively) and histone H4 at 'Arg-3' (to form H4R3ci). Acts as a key regulator of stem cell maintenance by mediating citrullination of histone H1: citrullination of 'Arg-54' of histone H1 (H1R54ci) results in H1 displacement from chromatin and global chromatin decondensation, thereby promoting pluripotency and stem cell maintenance. Promotes profound chromatin decondensation during the innate immune response to infection in neutrophils by mediating formation of H1R54ci. Citrullination of histone H3 prevents their methylation by CARM1 and HRMT1L2/PRMT1 and represses transcription. Citrullinates EP300/P300 at 'Arg-2142', which favors its interaction with NCOA2/GRIP1.