Bovine Purinergic receptor P2Y, G-protein coupled, 12 ELISA Kit | P2Y12 elisa kit

Bovine Purinergic receptor P2Y, G-protein coupled, 12 ELISA Kit

Cat. Num. AAA755582

• Gene Names: P2RY12; HORK3; P2Y12; ADPG-R; BDPLT8; SP1999; P2T(AC); P2Y(AC); P2Y(12)R; P2Y(ADP); P2Y(cyc)
• Reactivity: Bovine
• Synonyms: Purinergic receptor P2Y; G-protein coupled; 12; Bovine Purinergic receptor P2Y; 12 ELISA Kit; P2Y12 elisa kit

• Reactivity: Bovine

• Samples: Serum, plasma, Cell Culture Supernatants, body fluid and tissue homogenate
• Sensitivity: 0.1 ng/mL.
• Intended Uses: This P2Y12 ELISA kit is a 1.5 hour solid-phase ELISA designed for the quantitative determination of Bovine P2Y12. This ELISA kit for research use only, not for therapeutic applications!
• Preparation and Storage: Store all reagents at 2-8 degree C.

Typical Testing Data/Standard Curve (for reference only)

NCBI and Uniprot Product Information

• NCBI GI #: 17389767
• NCBI GeneID: 64805
• Molecular Weight: 39,439 Da
• NCBI Official Full Name: Purinergic receptor P2Y, G-protein coupled, 12
• NCBI Official Synonym Full Names: purinergic receptor P2Y, G-protein coupled, 12
• NCBI Official Symbol: P2RY12
• NCBI Official Synonym Symbols: HORK3; P2Y12; ADPG-R; BDPLT8; SP1999; P2T(AC); P2Y(AC); P2Y(12)R; P2Y(ADP); P2Y(cyc)
• NCBI Protein Information: P2Y purinoceptor 12; ADP-glucose receptor; purinergic receptor P2RY12; P2Y12 platelet ADP receptor; Gi-coupled ADP receptor HORK3; G-protein coupled receptor SP1999; putative G-protein coupled receptor
• UniProt Protein Name: P2Y purinoceptor 12
• UniProt Gene Name: P2RY12
• UniProt Synonym Gene Names: HORK3; P2Y12; ADPG-R; P2Y(ADP)
• UniProt Entry Name: P2Y12_HUMAN

NCBI Description

The product of this gene belongs to the family of G-protein coupled receptors. This family has several receptor subtypes with different pharmacological selectivity, which overlaps in some cases, for various adenosine and uridine nucleotides. This receptor is involved in platelet aggregation, and is a potential target for the treatment of thromboembolisms and other clotting disorders. Mutations in this gene are implicated in bleeding disorder, platelet type 8 (BDPLT8). Alternative splicing results in multiple transcript variants of this gene. [provided by RefSeq, Jul 2013]

Uniprot Description

P2Y12: Receptor for ADP and ATP coupled to G-proteins that inhibit the adenylyl cyclase second messenger system. Not activated by UDP and UTP. Involved in platelets aggregation. Defects in P2RY12 are the cause of bleeding disorder platelet-type 8 (BDPLT8). A condition characterized by mild to moderate mucocutaneous bleeding, and excessive bleeding after surgery or trauma. The defect is due to severe impairment of platelet response to ADP resulting in defective platelet aggregation. Belongs to the G-protein coupled receptor 1 family.

Protein type: Receptor, GPCR; GPCR, family 1; Mitochondrial; Membrane protein, multi-pass; Membrane protein, integral

Chromosomal Location of Human Ortholog: 3q25.1

Cellular Component: cell surface; mitochondrion; integral to plasma membrane; plasma membrane; basal plasma membrane; intrinsic to membrane; caveola; external side of plasma membrane

Molecular Function: guanyl-nucleotide exchange factor activity; adenosine receptor activity, G-protein coupled; platelet ADP receptor activity

Biological Process: platelet activation; G-protein coupled receptor protein signaling pathway; negative regulation of cell differentiation; cell projection organization and biogenesis; hemostasis; protein kinase B signaling cascade; positive regulation of ion transport; regulation of calcium ion transport; G-protein signaling, adenylate cyclase inhibiting pathway; blood coagulation; adenosine receptor signaling pathway; positive regulation of GTPase activity

Disease: Bleeding Disorder, Platelet-type, 8