P2X4 / P2X4R Blocking Peptide | P2RX4 blocking peptide
P2X4 / P2X4R Immunizing Peptide
NCBI and Uniprot Product Information
NCBI Description
The product of this gene belongs to the family of purinoceptors for ATP. This receptor functions as a ligand-gated ion channel with high calcium permeability. The main pharmacological distinction between the members of the purinoceptor family is the relative sensitivity to the antagonists suramin and PPADS. The product of this gene has the lowest sensitivity for these antagonists. Multiple alternatively spliced transcript variants, some protein-coding and some not protein-coding, have been found for this gene. [provided by RefSeq, Feb 2012]
Uniprot Description
P2X4: Receptor for ATP that acts as a ligand-gated ion channel. This receptor is insensitive to the antagonists PPADS and suramin. Belongs to the P2X receptor family.
Protein type: Channel, ligand-gated; Membrane protein, integral; Membrane protein, multi-pass
Chromosomal Location of Human Ortholog: 12q24.32
Cellular Component: cell junction; cell soma; dendritic spine; integral to nuclear inner membrane; integral to plasma membrane; lysosomal membrane; membrane; perinuclear region of cytoplasm; plasma membrane; postsynaptic density; terminal button
Molecular Function: ATP binding; ATP-gated cation channel activity; cadherin binding; copper ion binding; drug binding; protein binding; protein homodimerization activity; purinergic nucleotide receptor activity; receptor binding; zinc ion binding
Biological Process: blood coagulation; endothelial cell activation; generation of action potential; membrane depolarization; positive regulation of calcium ion transport; positive regulation of calcium-mediated signaling; positive regulation of nitric oxide biosynthetic process; positive regulation of prostaglandin secretion; protein homooligomerization; regulation of blood pressure; regulation of sodium ion transport; response to ATP; sensory perception of pain; signal transduction; tissue homeostasis; transport
Research Articles on P2RX4
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Product Notes
The P2RX4 p2rx4 (Catalog #AAA428506) is a Blocking Peptide and is intended for research purposes only. The product is available for immediate purchase. The P2X4 / P2X4R Immunizing Peptide reacts with Human, Mouse, Rat, Dog, Cow and may cross-react with other species as described in the data sheet. The amino acid sequence is listed below: C-YREKKYKY VEDYEQ. It is sometimes possible for the material contained within the vial of "P2X4 / P2X4R, Blocking Peptide" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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