Protein FAM105B (Fam105b) Recombinant Protein | Fam105b recombinant protein

Recombinant Mouse Protein FAM105B (Fam105b)

Cat. Num. AAA1308790

• Gene Names: Otulin; C79097; m3Sapc; Fam105b; m7-1Sapc
• Purity: Greater or equal to 85% purity as determined by SDS-PAGE.
• Synonyms: Protein FAM105B (Fam105b); Recombinant Mouse Protein FAM105B (Fam105b); Fam105b recombinant protein

• Host: E Coli or Yeast or Baculovirus or Mammalian Cell
• Purity/Purification: Greater or equal to 85% purity as determined by SDS-PAGE.
• Form/Format: Lyophilized or liquid (Format to be determined during the manufacturing process)
• Sequence Positions: 1-352, full length protein
• Sequence: MSRGTMPQPGAWPGASCAETPAREAGAAARDGGKVTAGAQPRAATRCPAEHEEDMYRAADEIEKEKELLIHERGISEPRLSVAPEMDIMDYCKKEWRGNTQKATCMKKGYEEVSQKFTSIRRVRGDNYCALRATLFQAMSQLAELPPWLQDLELILLPEKLINKYTWIKQWKLGLKFDGKSEDLVEKIKESLALLRKKWVSLAAMKTAEARQTACDELFTNEEEEYSLYEAVKFLMLNRAIELYDDKEKGKEVPFFSVLLFARDTSNDPEQLLRNHLNQVGHTGGLEQVEMFLLAYAVRHSIRVYRLSKYNTEEFITVYPTDPPKDWPMVTLIAEDDRHYNIPVRVCEETSV
• Sequence Length: 352

• Species: Mouse
• Preparation and Storage: Store at -20 degrees C. For long-term storage, store at -20 degrees C or -80 degrees C. Store working aliquots at 4 degrees C for up to one week. Repeated freezing and thawing is not recommended.

NCBI and Uniprot Product Information

• NCBI GI #: 164519048
• NCBI GeneID: 432940
• NCBI Accession #: NP_001013814.2
• NCBI GenBank Nucleotide #: NM_001013792.2
• UniProt Accession #: Q3UCV8; Q3UY59; Q5M8N1; Q8R027
• Molecular Weight: 40,320 Da
• NCBI Official Full Name: ubiquitin thioesterase otulin
• NCBI Official Synonym Full Names: OTU deubiquitinase with linear linkage specificity
• NCBI Official Symbol: Otulin
• NCBI Official Synonym Symbols: C79097; m3Sapc; Fam105b; m7-1Sapc
• NCBI Protein Information: ubiquitin thioesterase otulin
• UniProt Protein Name: Ubiquitin thioesterase otulin
• UniProt Gene Name: Otulin

Uniprot Description

Deubiquitinase that specifically removes linear ('Met-1'-linked) polyubiquitin chains to substrates and acts as a regulator of angiogenesis and innate immune response (PubMed:23708998, PubMed:27523608). Associates with the LUBAC complex via direct interaction with RNF31 and counteracts its action by cleaving linear polyubiquitin chains to substrates (PubMed:23708998, PubMed:27523608). Required during angiogenesis, craniofacial and neuronal development by regulating the canonical Wnt signaling together with the LUBAC complex (PubMed:23708998). Acts as a negative regulator of NF-kappa-B by counteracting activity of the LUBAC complex (). Required for homeostasis of the LUBAC complex by restricting autoubiquination of the LUBAC complex subunit RNF31 (). Some results have suggested that OTULIN function is restricted to homeostasis of the LUBAC complex, because it is not stably associated with TNF or NOD2 receptor signaling complexes (RSCs) (). However, further report have shown that it plays active roles in receptor signaling (). Acts as a key negative regulator of inflammation by restricting spontaneous inflammation and maintaining immune homeostasis (PubMed:27523608). In myeloid cell, required to prevent unwarranted secretion of cytokines leading to inflammation and autoimmunity by restricting linear polyubiquitin formation (PubMed:27523608). Plays a key role in innate immune response by restricting linear polyubiquitin formation on RIPK2 in response to NOD2 stimulation, probably to limit NOD2-dependent proinflammatory signaling ().