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Oncostatin M Recombinant Protein | OSMR recombinant protein
Recombinant Oncostatin M Receptor (OSMR)
Source: Prokaryotic expression
W KWSDWTQKEF STPETAPSQA LDVWRQVWSE NGRRIVTLFW KPLLKSQANG KIISYNIVVE NEAKPTESEH YCVWAPALST NLSLDLQPYK IRITTNNSMG ASPESLMVLS NDSGHEEVKE KTIKGIKDAF NISWEPVSGD TMGYVVDWCA HSQDQRCDLQ WKNLGPNTTS TTITSDDFKP GVRYNFRIFE RSVEHKARLV EKQRGYTQEL APLVNPKVEIPYSTPNSFVL RWPDYDSDFQ AG
Stability Test: The thermal stability is described by the loss rate of the targetprotein. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37 degree C for 48h, and no obvious degradation andprecipitation were observed. The loss of this protein is less than 5% within the expiration date under appropriate storage condition.
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NCBI and Uniprot Product Information
NCBI Description
Oncostatin M is a member of a cytokine family that includes leukemia-inhibitory factor, granulocyte colony-stimulating factor, and interleukin 6. This gene encodes a growth regulator which inhibits the proliferation of a number of tumor cell lines. It regulates cytokine production, including IL-6, G-CSF and GM-CSF from endothelial cells. [provided by RefSeq, Jul 2008]
Uniprot Description
OSM: Growth regulator. Inhibits the proliferation of a number of tumor cell lines. Stimulates proliferation of AIDS-KS cells. It regulates cytokine production, including IL-6, G-CSF and GM-CSF from endothelial cells. Uses both type I OSM receptor (heterodimers composed of LIPR and IL6ST) and type II OSM receptor (heterodimers composed of OSMR and IL6ST). Involved in the maturation of fetal hepatocytes, thereby promoting liver development and regeneration. Belongs to the LIF/OSM family.
Protein type: Secreted; Cytokine; Secreted, signal peptide
Chromosomal Location of Human Ortholog: 22q12.2
Cellular Component: extracellular space
Molecular Function: growth factor activity; oncostatin-M receptor binding; cytokine activity
Biological Process: negative regulation of hormone secretion; multicellular organismal development; tyrosine phosphorylation of Stat3 protein; positive regulation of peptidyl-serine phosphorylation; tyrosine phosphorylation of Stat5 protein; peripheral nervous system development; negative regulation of cell proliferation; cell proliferation; positive regulation of peptidyl-tyrosine phosphorylation; behavioral response to pain; positive regulation of MAPKKK cascade; positive regulation of acute inflammatory response; response to heat; positive regulation of cell division; regulation of growth; negative regulation of meiosis; positive regulation of cell proliferation; tyrosine phosphorylation of Stat1 protein; positive regulation of transcription from RNA polymerase II promoter; immune response
Research Articles on OSMR
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Product Notes
The OSMR osm (Catalog #AAA2031280) is a Recombinant Protein produced from Host: E Coli Source: Prokaryotic expression and is intended for research purposes only. The product is available for immediate purchase. AAA Biotech's Oncostatin M can be used in a range of immunoassay formats including, but not limited to, SDS-PAGE, Western Blot (WB), ELISA (EIA), Immunoprecipitation (IP). Researchers should empirically determine the suitability of the OSMR osm for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. The amino acid sequence is listed below: The target protein is fused with two N-terminal Tags, His-tag and GST-tag, its sequence is listed below.W KWSDWTQKEF STPETAPSQA LDVWRQVWSE NGRRIVTLFW KPLLKSQANG KIISYNIVVE NEAKPTESEH YCVWAPALST NLSLDLQPYK IRITTNNSMG ASPESLMVLS NDSGHEEVKE KTIKGIKDAF NISWEPVSGD TMGYVVDWCA HSQDQRCDLQ WKNLGPNTTS TTITSDDFKP GVRYNFRIFE RSVEHKARLV EKQRGYTQEL APLVNPKVEI PYSTPNSFVL RWPDYDSDFQ AG. It is sometimes possible for the material contained within the vial of "Oncostatin M, Recombinant Protein" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.
Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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