Odorant receptor 22b (Or22b) Recombinant Protein | Or22b recombinant protein
Recombinant Drosophila melanogaster Odorant receptor 22b (Or22b)
NCBI and Uniprot Product Information
Uniprot Description
Function: Complexes with Orco to form odorant-sensing units, providing sensitive and prolonged odorant signaling and calcium permeability. They are necessary and sufficient to promote functional reconstitution of odor-evoked signaling in sensory neurons that normally respond only to carbon dioxide. Ref.8
Subunit structure: Interacts with Orco, via conserved C-terminal cytoplasmic loops. Complexes exist early in the endomembrane system in olfactory sensory neurons (OSNs), coupling these complexes to the conserved ciliary trafficking pathway. Ref.8
Subcellular location: Cell membrane; Multi-pass membrane protein
By similarity.
Tissue specificity: Expressed with Orco in 20-22 sensory neurons on the medial-proximal edge of the antenna. This expression pattern matches the distribution of the large sensilla basiconica. Expression is first seen at 60 hours APF in a subset of cells restricted to a subregion of the developing antenna. Expression continues throughout antennal development. Ref.1 Ref.7 Ref.8
Miscellaneous: The atypical heteromeric and topological design of the odorant receptors appears to be an insect-specific solution for odor recognition, making the OR/Orco complex an attractive target for the development of highly selective insect repellents to disrupt olfactory-mediated host-seeking behaviors of insect disease vectors. Odor-evoked OR currents are independent of known G-protein-coupled second messenger pathways.
Sequence similarities: Belongs to the heteromeric odorant receptor channel (TC 1.A.69) family. [View classification]
Sequence caution: The sequence CAR79088.1 differs from that shown. Reason: Intron retention and rearrangment of DNA.
Research Articles on Or22b
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Product Notes
The Or22b or22b (Catalog #AAA1205087) is a Recombinant Protein produced from E Coli or Yeast or Baculovirus or Mammalian Cell and is intended for research purposes only. The product is available for immediate purchase. The immunogen sequence is 1-397. The amino acid sequence is listed below: MLSQFFPHIK EKPLSERVKS RDAFVYLDRV MWSFGWTVPE NKRWDLHYKL WSTFVTLLIF ILLPISVSVE YIQRFKTFSA GEFLSSIQIG VNMYGSSFKS YLTMMGYKKR QEAKMSLDEL DKRCVCDEER TIVHRHVALG NFCYIFYHIA YTSFLISNFL SFIMKRIHAW RMYFPYVDPE KQFYISSIAE VILRGWAVFM DLCTDVCPLI SMVIARCHIT LLKQRLRNLR SEPGRTEDEY LKELADCVRD HRLILDYVDA LRSVFSGTIF VQFLLIGIVL GLSMINIMFF STLSTGVAVV LFMSCVSMQT FPFCYLCNMI MDDCQEMADS LFQSDWTSAD RRYKSTLVYF LHNLQQPIIL TAGGVFPISM QTNLNMVKLA FTVVTIVKQF NLAEKFQ. It is sometimes possible for the material contained within the vial of "Odorant receptor 22b (Or22b), Recombinant Protein" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
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