Osteomodulin Recombinant Protein | OMD recombinant protein

Osteomodulin Protein, Human, Recombinant (His Tag)

Cat. Num. AAA8120506

• Gene Names: OMD; OSAD; SLRR2C
• Purity: >95% as determined by SDS-PAGE
• Synonyms: Osteomodulin; Osteomodulin Protein; Human; Recombinant (His Tag); Human Osteomodulin/OMD Protein (His Tag); OSAD Protein; SLRR2C Protein; osteomodulin; OMD recombinant protein

• Host: HEK293 Cells
• Purity/Purification: >95% as determined by SDS-PAGE
• Form/Format: Lyophilized from sterile PBS, pH7.4. Normally 5%-8% trehalose, mannitol and 0.01% Tween80 are added as protectants before lyophilization. Please refer to the specific buffer information in the hard copy of CoA.
• Sequence: Met1-Glu421

• Species: Human
• Endotoxin: <1.0EU per ug protein as determined by the LAL method.
• Predicted N Terminal: Gln 21
• Tag: C-His
• Protein Construction: A DNA sequence encoding the human OMD (NP_005005.1)(Met1-Glu421) was expressed with a polyhistidine tag at the C-terminus.
• Reconstitution: A hardcopy of COA with reconstitution instruction is sent along with the products. Please refer to it for detailed information.
• Preparation and Storage: Samples are stable for up to twelve months from date of receipt at -20 degree C to -80 degree C. Store it under sterile conditions at -20 degree C to -80 degree C. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.; In general, recombinant proteins are provided as lyophilized powder which are shipped at ambient temperature. Bulk packages of recombinant proteins are provided as frozen liquid.; They are shipped out with blue ice.

SDS-Page

Related Product Information for OMD recombinant protein

Background: Osteomodulin (OMD), also known as Osteoadherin (OSAD), Keratan sulfate proteoglycan osteomodulin, KSPG osteomodulin, and SLRR2C, is a secreted protein that belongs to the small leucine-rich proteoglycan (SLRP) family and Class II subfamily. SLRP family proteins are normally found in extracellular matrices, but Osteomodulin is the only member restricted to mineralized tissues. Osteomodulin is primarily expressed by osteoblasts and might have a role in the regulation of mineralization. In bone, OSAD has been localized in the primary spongiosa within the bovine fetal rib growth plate. Moreover, in situ hybridization has shown expression of OSAD in osteoblasts close to the cartilage and bone border in the growth plate of rat femur. OSAD may play an important role during tooth development and biomineralization of dentin. Osteomodulin is a cell binding keratan sulfate proteoglycan that was recently isolated from mineralized bovine bone and subsequently cloned and sequenced. Osteomodulin may be implicated in biomineralization processes. It has a function in the binding of osteoblasts via the alpha (V) beta (3)-integrin. Osteomodulin is likely an osteoblast maturation marker that is induced by osteoclast activity. Osteomodulin is also an early marker for terminally differentiated matrix producing osteoblasts.

References

Buchaille R, et al. (2000) Expression of the small leucine-rich proteoglycan osteoadherin/osteomodulin in human dental pulp and developing rat teeth. Bone. 27(2): 265-70.Petersson U, et al. (2003) Identification, distribution and expression of osteoadherin during tooth formation. Eur J Oral Sci. 111(2): 128-36.Rehn AP, et al. (2006) Differential regulation of osteoadherin (OSAD) by TGF-beta1 and BMP-2. Biochem Biophys Res Commun. 349(3): 1057-64.

NCBI and Uniprot Product Information

• NCBI GI #: 4826876
• NCBI GeneID: 4958
• NCBI Accession #: NP_005005.1
• NCBI GenBank Nucleotide #: NM_005014.2
• UniProt Accession #: Q99983; Q5TBF4
• Molecular Weight: 49,492 Da
• NCBI Official Full Name: osteomodulin
• NCBI Official Synonym Full Names: osteomodulin
• NCBI Official Symbol: OMD
• NCBI Official Synonym Symbols: OSAD; SLRR2C
• NCBI Protein Information: osteomodulin; KSPG osteomodulin; OTTHUMP00000021653; osteoadherin proteoglycan; keratan sulfate proteoglycan osteomodulin
• UniProt Protein Name: Osteomodulin
• Protein Family: Osteomodulin
• UniProt Gene Name: OMD
• UniProt Synonym Gene Names: SLRR2C; KSPG osteomodulin; OSAD
• UniProt Entry Name: OMD_HUMAN