Oxidized low-density lipoprotein receptor 1 (Olr1) Recombinant Protein | Olr1 recombinant protein

Recombinant Rat Oxidized low-density lipoprotein receptor 1 (Olr1)

• Gene Names: Olr1; LOX-1; Oldr1; Oldlr1
• Purity: Greater or equal to 85% purity as determined by SDS-PAGE.
• Synonyms: Oxidized low-density lipoprotein receptor 1 (Olr1); Recombinant Rat Oxidized low-density lipoprotein receptor 1 (Olr1); Oxidized low-density lipoprotein receptor 1; Ox-LDL receptor 1; Lectin-like oxidized LDL receptor 1; LOX-1; Lectin-like oxLDL receptor 1; Lectin-type oxidized LDL receptor 1Cleaved into the following chain:; 1. Oxidized low-density lipoprotein receptor 1; ; Olr1 recombinant protein

• Host: E Coli or Yeast or Baculovirus or Mammalian Cell
• Purity/Purification: Greater or equal to 85% purity as determined by SDS-PAGE.
• Form/Format: Lyophilized or liquid (Format to be determined during the manufacturing process)
• Sequence Positions: 55-364
• Sequence: QQTQLL QVSDLLKQYQ ANLTQQDHIL EGQMSAQKKA ENASQESKRE LKEQIDTLTW KLNEKSKEQE KLLQQNQNLQ EALQRAVNAS EESKWELKEQ IDILNWKLNG ISKEQKELLQ QNQNLQEALQ KAEKYSEESQ RELKEQIDTL SWKLNEKSKE QEELLQQNQN LQEALQRAAN SSGPCPQDWI WHKENCYLFH GPFNWEKSRE NCLSLDAQLL QISTTDDLNF VLQATSHSTS PFWMGLHRKN PNHPWLWENG SPLSFQFFRT RGVSLQMYSS GTCAYIQGGV VFAENCILTA FSICQKKANL LLTQ
• Sequence Length: 310

• Species: Rattus norvegicus (Rat)
• Preparation and Storage: Store at -20 degrees C. For long-term storage, store at -20 degrees C or -80 degrees C. Store working aliquots at 4 degrees C for up to one week. Repeated freezing and thawing is not recommended.

NCBI and Uniprot Product Information

• NCBI GI #: 404247470
• NCBI GeneID: 140914
• NCBI Accession #: NP_579840.2
• NCBI GenBank Nucleotide #: NM_133306.2
• UniProt Accession #: O70156
• Molecular Weight: 41,890 Da
• NCBI Official Full Name: oxidized low-density lipoprotein receptor 1
• NCBI Official Synonym Full Names: oxidized low density lipoprotein (lectin-like) receptor 1
• NCBI Official Symbol: Olr1
• NCBI Official Synonym Symbols: LOX-1; Oldr1; Oldlr1
• NCBI Protein Information: oxidized low-density lipoprotein receptor 1; ox-LDL receptor 1; lectin-like oxLDL receptor 1; lectin-like oxidized LDL receptor 1; lectin-type oxidized LDL receptor 1; lectin-like oxidized low-density lipoprotein receptor; Lectin-like oxidized low-density lipoprotein receptor-1; oxidised low density lipoprotein (lectin-like) receptor 1
• UniProt Protein Name: Oxidized low-density lipoprotein receptor 1
• Protein Family: Oxidized low-density lipoprotein receptor
• UniProt Gene Name: Olr1
• UniProt Synonym Gene Names: Lox1; Oldlr1; Ox-LDL receptor 1; LOX-1; Lectin-like oxLDL receptor 1
• UniProt Entry Name: OLR1_RAT

NCBI Description

receptor for oxidized low-density lipoprotein that may be involved in pathogenesis of hypertension as well as atherosclerosis [RGD, Feb 2006]

Uniprot Description

Receptor that mediates the recognition, internalization and degradation of oxidatively modified low density lipoprotein (oxLDL) by vascular endothelial cells. OxLDL is a marker of atherosclerosis that induces vascular endothelial cell activation and dysfunction, resulting in pro-inflammatory responses, pro-oxidative conditions and apoptosis. Its association with oxLDL induces the activation of NF-kappa-B through an increased production of intracellular reactive oxygen and a variety of pro-atherogenic cellular responses including a reduction of nitric oxide (NO) release, monocyte adhesion and apoptosis. In addition to binding oxLDL, it acts as a receptor for the HSP70 protein involved in antigen cross-presentation to naive T-cells in dendritic cells, thereby participating in cell-mediated antigen cross-presentation. Also involved in inflammatory process, by acting as a leukocyte-adhesion molecule at the vascular interface in endotoxin-induced inflammation. Also acts as a receptor for advanced glycation end (AGE) products, activated platelets, monocytes, apoptotic cells and both Gram-negative and Gram-positive bacteria.